1445985-69-2

Upstream product

• 1224640-10-1 N-cyclopropyl-N-(2-nitro-phenyl)-oxalamic acid methyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 
• 55432-23-0 cyclopropyl-(2-nitro-phenyl)-amine 
• 1445985-68-1 (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-hydroxybut-1-ynyl)phenoxy)methyl)cyclopropyl)methanone 
• 1445985-67-0 (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-iodophenoxy)methyl)cyclopropyl)methanone 
• 1445985-66-9 (1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)methyl methanesulfonate 
• 1445985-65-8 (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-(hydroxymethyl)cyclopropyl)methanone 
• 1445985-62-5 methyl 1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropanecarboxylate 
• 1276078-72-8 1-chlorocarbonyl-1-cyclopropanecarboxylic acid methyl ester 
• 113020-21-6 1,1-cyclopropanedicarboxylic acid monomethyl ester 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 
• 1224640-13-4 1-cyclopropyl-1,2,3,4-tetrahydro-quinoxaline 
• 1224640-12-3 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione 
• 1224640-11-2 1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione 

Downstream Products

• 1445983-44-7 (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-(methyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)butyl)phenoxy)methyl)cyclopropyl)methanone trifluoroacetate 
• 1445985-70-5 4-(2,5-dichloro-4-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)methoxy)phenyl)butyl methanesulfonate 

Relevant academic research and scientific papers

NON-SYSTEMIC TGR5 AGONISTS

Compounds of structure (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, R3, R4, R8, R9, R10, R11, R12, A1, A2, X, Y and Z are as defined herein. Uses of such compounds as TGR5 antagonists and for treatment of various indications, including Type II diabetes meletus are also provided.