14467-69-7Relevant articles and documents
Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques
Jia, Jianhua,Zhang, Longfei,Song, Jia,Dai, Jiapei,Cui, Mengchao
, p. 4089 - 4100 (2020/12/13)
The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for β-amyloid (Aβ) binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthesized and evaluated. Most of them displayed good affinity (Ki1-42aggregates, and some ligands even showed values of Kiless than 10 nM. Structure-activity relationship analysis revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development of Aβ imaging agents.
Green synthesis of symmetric aryl ether dinitro compounds in deep eutectic solvents
Jin, Yan,Ding, Yinhao,Hou, Xichao,Dong, Jingjing,Lu, Jianqiang,Feng, Baicheng
, p. 101 - 107 (2020/03/17)
A series of symmetric aryl ether dinitro compounds were synthesized by 4Urea/ZnCl2 as green solvent and catalyst, and halogenated aromatic hydrocarbon derivatives and dihydroxy compounds as raw materials. This method has the advantages of easy operation, simple recrystallization, environmental friendliness and biodegradability. The structures of the products were subjected to 1H NMR, and the reaction conditions, reaction mechanism and greening advantages of deep eutectic solvents were discussed at the end of the experiments. We learned from the results of the experiments that both the aliphatic dihydroxy compounds and the aromatic dihydroxy compounds could proceed effectively in Ullmann reaction, and the desired products could be obtained in acceptable yields. When using this methodology, symmetric aryl ether dinitro compounds could be synthesized simply at 80oC in 2 h with high yields (66%~94%). Meanwhile, the DES, called deep eutectic solvent which is composed of 4Urea/ZnCl2, could be recycled at least five times without an obvious decraese in the catalytic activity.
Liquid crystal dimers having vary oxyethylene flexible spacers
Park, Joo Hoon,Singu, Bal Sydulu,Choi, Ok Byung,Lee, Hwan Myung,Lee, Jin Young,Kim, Sung Jo,Cha, Eun Hee,Park, Seon Nam,Kwak, Myeong Heon,So, Bong Keun,Kim, Ran Hee,Lee, Soo Min,Yoon, Kuk Ro
, p. 1 - 6 (2017/09/07)
In this article, we are prepared that the liquid crystal dimers have aromatic-ester type mesogenic units or aromatic-Schiff base type mesogonic units and confirmed by 1H-NMR spectrometry. The mesomorphic and optical properties of the resultant dimers were studied by differential scanning calorimetry and polarizing optical microscopy.
New optically active Organo-soluble poly(amide-Imide)s from [N,N?-(4,4?- Diphtaloyl)-BIS-l-amino Diacid]s and 1,2-bis[4,4'-aminophenoxy] ethane: Synthesis and characterization
Feyzi, Akram,Faghihi, Khalil,Raeisi, Ahamd,Koushki, Maryam,Farahani, Mansoure
, p. 1884 - 1887 (2014/03/21)
Six new dicarboxylic acids 3a-f were synthesized by the reaction of 3,3?,4,4?-biphenyltetracarboxylic dianhydride (BPDA) 1 with L-amino acids 2a-f in a solution of glacial acetic acid/pyridine (Py) at refluxing temperature. Then six new optically active p
Alkoxylation of 4-chloronitrobenzene with aliphatic alcohols and glycols in the presence of NaOH
Malykhin, E. V.,Shteingarts, V. D.
, p. 1232 - 1238,7 (2020/09/09)
The reaction of 4-chloronitrobenzene with aliphatic C1-n-C 4 alcohols and with mono-, di-, and triethylene glycols in the presence of NaOH in liquid ammonia at 15-50°C was studied.
Preparation of new optically active and thermally stable poly(amide-imide) containing bicyclo segment and ether group in the main chain by direct polycondensation in two different media
Faghihi, Khalil,Shabanian, Meisam
scheme or table, p. 491 - 496 (2011/12/02)
A new series of optically active and thermally stable poly(amide-imide)s (PAIs) with good inherent viscosities based on bicyclo diacids and etheric diamine in the main chain were synthesized from the direct polycondensation reaction of N,N?-(bicyclo[2,2,2
Synthesis of symmetric liquid crystal dimers based on 1,2-bis{-[-(4- alkoxybenzoyloxy)benzylidene]amino)phenoxy}ethane and investigation of phase behaviour by varying alkoxy terminal chain length
Lee, Chang Sin,Kim, Tae Hyeong,Ramaraj,Ryu, Seok Gn,Song, Hyun Hoon,Lee, Soo-Min,Yoon, Kuk Ro
experimental part, p. 117 - 129 (2010/03/03)
With the objective to study the effect of alkoxy terminal chain length on mesomorphic properties of liquid crystals, We have synthesized ester and Schiff base dimers from diamine derivative containing 1,2-dioxyethylene as short spacer with aldehyde deriva
Synthesis and Properties of a New Series of Troegerophanes
Ibrahim, Alhussein A.,Matsumoto, Mutsumi,Miyahara, Yuji,Izumi, Kenji,Suenaga, Masahiko,Shimizu, Nobujiro,Inazu, Takahiko
, p. 209 - 215 (2007/10/03)
A new series of macrocyclic compounds with one or two Troeger base skeletons has been synthesized by condensing mono-, di-, tri-, and teraethyleneglycol bis(p-aminophenoxy) ethers with formalin in the presence of concentrated hydrochloric acid in ethanol at room temperature for 13 days. This simple one-step cyclization provided 19 in remarkably high yield (46%) and 17, 18, and 20 in yields reflecting the strain of the rings and statistical factors. Complexation with lithium thiocyanate was observed for 20, the structure of which was elucidated by X-ray crystallography.
Dipole Moments and UV Spectra of some Long-chain Molecules
Baliah, V.,Aparajithan, K.
, p. 255 - 259 (2007/10/02)
About one hundred compounds with long-chain molecular structure have been prepared (most of them are new).The dipole moments of four α,ω-bis(p-methoxyphenylthio)alkanes and five α,ω-bis(p-methoxyphenylsulphonyl)alkanes have been determined to find the effect of chain-length.In the case of sulphones, the observed values are compared with the values calculated for free rotation around all bonds intervening the end dipoles.The uv spectra of some 1,2-(distyrylsulphonyl)ethanes, and a number of α,ω-bis(arylsulphonyl)- and α,ω-bis(aryloxy)alkanes have been recorded to examine the applicability of the principle of chromophore additivity.
