1453499-97-2

Upstream product

• 1453499-95-0 1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone 
• 959632-18-9 (4-iodo-3-methylphenyl)methanol 
• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 1453499-96-1 2-bromo-1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone 
• 149104-89-2 4-bromo-3-methylbenzylalcohol 
• 100-39-0 benzyl bromide 
• 626-03-9 3-deazauracil 

Downstream Products

• 1453498-94-6 4-benzyloxy-1-{2-[4-(3-hydroxy-azetidin-1-ylmethyl)-2-methyl-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one 
• 1453499-05-2 4-benzyloxy-1-{2-[4-(3-hydroxy-3-methyl-pyrrolidin-1-ylmethyl )-2-methyl-phenyl]-2-oxo-ethyl}-1H-pyridin-2-one 
• 1453499-98-3 4-benzyloxy-1-[2-(4-{bromomethyl}-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one 
• 1453499-01-8 4-(benzyloxy)-1-(2-(4-((dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)pyridin-2(1H)-one 

Relevant academic research and scientific papers

Design, synthesis and evaluation of MCH receptor 1 antagonists - Part III: Discovery of pre-clinical development candidate BI 186908

Abstract Although overweight and obesity are highly prevalent conditions, options to treat them are still very limited. As part of our search for safe and effective MCH-R1 antagonists for the treatment of obesity, two series of pyridones and pyridazinones

NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present invention relates to compounds of general formula I, wherein the groups R1, R2, L1, L2, U and B are as defined in the application, which have valuable pharmacological properties, and in particular modulate the activity of the MCH receptor.

PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS MCH - RECEPTOR MODULATORS

The present invention relates to compounds of general formula I, wherein the groups R1, R2, L1, L2, U and B are as defined in the application, which have valuable pharmacological properties, and in particular modulate the activity of the MCH receptor.