1456070-17-9

Basic information

• Product Name: C₂₁H₂₂ClFN₄O₃
• CAS NO: 1456070-17-9
• Molecular Weight: 432.882
• Mol File: 1456070-17-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₂ClFN₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₂ClFN₄O₃(1456070-17-9)
• EPA Substance Registry System: C₂₁H₂₂ClFN₄O₃(1456070-17-9)

Safety Data

• Hazardous Substances Data: 1456070-17-9(Hazardous Substances Data)

Upstream product

• 45347-82-8 azetidine-3-ol 
• 912556-91-3 6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine 
• 692059-41-9 6-(3-chloropropoxy)-4-chloro-7-methoxyquinazoline 
• 574738-93-5 6-(3-chloropropoxy)-7-methoxyquinazolin-4-ol 
• 380844-26-8 methyl 5-(3-chloropropoxy)-2-amino-4-methoxybenzoate 
• 380844-24-6 methyl 5-(3-chloropropoxy)-4-methoxy-2-nitrobenzoate 
• 380844-22-4 methyl 3-(3-chloropropoxy)-4-methoxybenzoate 
• 929683-54-5 3-(3-chloropropoxy)-4-methoxybenzaldehyde 
• 621-59-0 isovanillin 

Relevant articles and documents

Four-membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal growth factor receptor (EGFR) kinase inhibitors

We report herein the design and synthesis of novel azaspirocycle or azetidine substituted 4-anilinoquinazoline derivatives. The EGFR inhibitory activities and in vitro antitumor potency of these newly synthesized compounds against two lung cancer cell lines HCC827 and A549 were evaluated. Most of the target compounds possess good inhibitory potency. In particular, compounds 21g with 2-oxa-6-azaspiro[3.4]octane substituent was found to possess higher EGFR inhibitory activities and similar antitumor potency comparing to the lead compound gefitinib with improved water solubility.