Journal of Organic Chemistry p. 1025 - 1029 (1993)
Update date:2022-09-26
Topics: Synthesis Inhibitors Stereoselective synthesis Stereoselective HIV-1 protease
Ghosh, Arun K.
McKee, Sean P.
Thompson, Wayne J.
Darke, Paul L.
Zugay, Joan C.
The synthesis of a differentially protected dipeptide mimic 10 in enantiomerically pure form is described.The key step involves the epimerization of the C-2 center of the lactone 4, hydrolysis and protection of the resulting hydroxy acid, followed by Curt
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