Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic

Article abstract of DOI:10.1021/jo00057a011

The synthesis of a differentially protected dipeptide mimic 10 in enantiomerically pure form is described.The key step involves the epimerization of the C-2 center of the lactone 4, hydrolysis and protection of the resulting hydroxy acid, followed by Curt