14676-52-9

Basic information

• Product Name: 1,1'-Biphenyl-2-acetic acid
• Synonyms: 1,1'-Biphenyl-2-acetic acid;(2-Biphenylyl)acetic acid;Biphenyl-2-acetic acid;2-Biphenylacetic acid;2-([1,1'-Biphenyl]-2-yl)acetic acid;2-([1,1'-Biphenyl]-2-yl)
• CAS NO: 14676-52-9
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24388
• Mol File: 14676-52-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 402.2°Cat760mmHg
• Flash Point: 299°C
• Appearance: /
• Density: 1.165g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,1'-Biphenyl-2-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-Biphenyl-2-acetic acid(14676-52-9)
• EPA Substance Registry System: 1,1'-Biphenyl-2-acetic acid(14676-52-9)

Safety Data

• Hazardous Substances Data: 14676-52-9(Hazardous Substances Data)

Usage

General Description

1,1'-Biphenyl-2-acetic acid, also known as Biphenylacetic acid, is a synthetic organic compound with the chemical formula C14H12O2. It is a derivative of acetic acid and belongs to the class of biphenyl compounds. 1,1'-Biphenyl-2-acetic acid is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and structural features. It has been studied for its potential anti-inflammatory, analgesic, and antipyretic properties, and has shown promise as a drug candidate for the treatment of various conditions, including pain and inflammation. The compound has also been investigated for its potential use as an insecticide and fungicide due to its ability to disrupt insect growth and development. Overall, 1,1'-Biphenyl-2-acetic acid is a valuable chemical with diverse applications in the fields of medicine and agriculture.

Upstream product

• 186581-53-3 diazomethane 
• 14002-52-9 o-phenylbenzoyl chloride 
• 7647-01-0 hydrogenchloride 
• 19853-10-2 2-(biphenyl-2-yl)acetonitrile 
• 98-80-6 phenylboronic acid 
• 73739-93-2 methyl 2-(biphenyl-2-yl)acetate 
• 66370-75-0 methyl (2-iodophenyl)acetate 
• 20292-22-2 N,N-dimethyl-[1,1'-biphenyl]-2-methanamine 
• 124-38-9 carbon dioxide 
• 64-18-6 formic acid 
• 19853-09-9 2-phenylbenzyl bromide 
• 591-50-4 iodobenzene 
• 103-81-1 Benzeneacetamide 
• 1226855-77-1 2-biphenyl-2-ylacetamide 

Downstream Products

• 86-73-7 9H-fluorene 
• 484-17-3 9-Phenanthrol 
• 1618095-08-1 N-hydroxy-3-(4-(5-([1,1'-biphenyl]-2-ylmethyl)-1,3,4-oxadiazol-2-yl)phenyl)acrylamide 
• 1618094-74-8 C₂₄H₁₈N₂O₃ 
• 1618094-53-3 C₂₈H₂₆N₂O₃ 
• 1189141-81-8 1-(biphenyl-2-ylacetyl)-4-[(6-fluoro-2-naphthyl)methyl]-1,4-diazepane hydrochloride 
• 1189141-83-0 1-(biphenyl-2-ylacetyl)-4-[(6-fluoro-2-naphthyl)methyl]piperazine hydrochloride 
• 34751-44-5 C₂₂H₂₁NOS 
• 34743-06-1 2-Phenylphenylthioacet-(2.6-dimethylanilid) 
• 34743-30-1 2-Phenyl-phenylacet-<2.6-dimethylanilid> 
• 957-82-4 9-Acetoxy-phenanthren 

Relevant articles and documents

Tunable Single and Double γ-C?H Arylation of Phenylacetamides Directed by o-Aminophenols

The cheap and easily available o-aminophenols (OAPs) have been identified as practical directing component for the Pd-catalyzed aromatic γ-C?H bond arylation of phenylacetamides. Notably, the selective single and double arylation of the C?H bond(s) in the

Magnetic nanoparticles as an orthogonal support of polymer resins: Applications to solid-phase Suzuki cross-coupling reactions

Most of the reactants immobilized on conventional solid-phase resins are buried inside the interiors of lightly cross-linked polystyrene beads. An orthogonal support of solid-phase resins needs to be small enough to penetrate the interpolymeric chain spaces of a swollen resin to reach reaction sites. In this paper, we report the use of magnetic nanoparticles (～4 nm) as an orthogonal matrix to assist solid-phase reactions. A magnetic nanoparticle-supported homogeneous Pd catalyst was employed for promoting the Suzuki cross-coupling of an aryl halide on resins and an excessive arylboronic acid in solution. The workup separating three components (the catalyst, product, and remaining arylborate) is a chromatography-free process. The Pd catalyst was magnetically isolated and recycled from the reaction mixture by applying an external magnetic field. Then, a filtration process was followed to recover the excess borate reagent from the resins/product. Our work here presents the first example of an orthogonal matrix of solid-phase resins and shows the promise of employing nanomaterials in organic synthesis.

Hydroxyl-substituted phenanthrene derivative synthesis method

The invention relates to a hydroxyl-substituted phenanthrene derivative synthesis method, which includes taking a 2-carboxymethyl biphenyl compound as a raw material; and reacting under the action ofa catalyst to obtain a hydroxyl-substituted phenanthrene derivative, wherein the catalyst comprises one or two of trifluoromethanesulfonic acid or phosphorus pentoxide. Compared with the prior art, the synthesis method has the advantages of the cheap and easily-available catalyst, good universality of functional groups, simple and convenient operation, short reaction time, high reaction yield, mild reaction conditions and the like.

A General, Activator-Free Palladium-Catalyzed Synthesis of Arylacetic and Benzoic Acids from Formic Acid

A new catalyst for the carboxylative synthesis of arylacetic and benzoic acids using formic acid (HCOOH) as the CO surrogate was developed. In an improvement over previous work, CO is generated in situ without the need for any additional activators. Key to success was the use of a specific system consisting of palladium acetate and 1,2-bis((tert-butyl(2-pyridinyl)phosphinyl)methyl)benzene. The generality of this method is demonstrated by the synthesis of more than 30 carboxylic acids, including non-steroidal anti-inflammatory drugs (NSAIDs), under mild conditions in good yields.