14680-18-3

Upstream product

• 932-30-9 2-Hydroxybenzylamine 
• 98-88-4 benzoyl chloride 
• 55-21-0 benzamide 
• 132980-32-6 2-(1H-1,2,3-benzotriazol-1-ylmethyl)phenol 
• 90-02-8 salicylaldehyde 
• 21013-96-7 (E)-2-hydroxylbenzaldehyde oxime 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 1485-70-7 N-benzylbenzamide 
• 860554-67-2 2-(benzamidomethyl)phenyl benzoate 

Relevant academic research and scientific papers

Electrochemical Intramolecular Dehydrogenative Coupling of N-Benzyl(thio)amides: A Direct and Facile Synthesis of 4H-1,3-Benzoxazines and 4H-1,3-Benzothiazines

The electrochemical dehydrogenative cyclization of N-benzylamides was investigated with a Pt plate anode and graphite rod cathode in an undivided cell at room temperature. The oxidative degradation of the products was suppressed successfully and 4H-1,3-benzoxazines were obtained regardless of the substituents at the benzylic position. This method also allowed for the preparation of 4H-1,3-benzothiazines.

Efficient synthesis of substituted 3-acyl-3,4-dihydrobenzo[d][1,2,3]triazines

Acylated o-triazenylbenzylamines were cyclized to give 3-acyl-3,4-dihydrobenzo[d][1,2,3]triazines in good yields. Thus, a novel cyclization via a Jacobsen indazole-type reaction to aminoindazoles is observed in this context.

AROMATIC HYDROXYLATION OF BENZYLAMIDES BY POTASSIUM SUPEROXIDE

N-benzylamides react with potassium superoxide in benzene in presence of 18-crown-6 ether to give ortho and para hydroxylated products.A mechanism is proposed for this reaction, involving the nucleophilic attack of superoxide anion to amide carbonyl and hydrogen abstraction from benzyle methylene by the substrate-superoxide adduct.