14688-32-5

Upstream product

• 28918-09-4 2-benzyl-1,3-diphenyl-propane-1,3-dione 
• 14688-28-9 (3,5-diphenylisoxazol-4-yl)(phenyl)methanone 
• 26060-56-0 (1-phenylethylidene)(benzoyloxy)amine 
• 72705-83-0 4-benzyl-3-phenylisoxazol-5(4H)-one 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles: An efficient access to trisubstituted isoxazoles

The Suzuki-Miyaura cross-coupling of 3,4-disubstituted 5-bromoisoxazoles 1 at the C5 position has successfully proceeded in the presence of Pd2(dba)3 and P(t-Bu)3·HBF4 catalysts to give the corresponding trisubstituted isoxazoles 3 in good to high yields while suppressing the formation of ketone 4 as a byproduct. The use of bulky phosphine ligand P(t-Bu)3·HBF4 is essential for the current transformation, and the formation of ketone 4, which was a major product in the previous report, was able to be suppressed under the current conditions.

One-pot synthesis of isoxazoles from enaminones: An application of Fe(II) as the catalyst for ring expansion of 2H-azirine intermediates

We report an application of FeCl2 as an inexpensive, nontoxic, and efficient catalyst in a clean ring expansion reaction of 2H-azirine derivatives, an intermediate formed through the PhI(OAc)2-mediated azirination of readily availabl