26060-56-0

Usage

Uses

Used in Pharmaceutical Industry:
ACETOPHENONEO-BENZOYLOXIME is used as a reactant for the preparation of pyridines, which are important heterocyclic compounds with a wide range of applications in the pharmaceutical industry. These pyridines can be utilized as active pharmaceutical ingredients or as key building blocks in the synthesis of various drugs.
ACETOPHENONEO-BENZOYLOXIME is used as a reactant for [application type] in the preparation of pyridines by iron-catalyzed cyclization of ketoxime acetates and tertiary N,N-dialkylanilines. This process is significant because it allows for the efficient synthesis of pyridines, which are valuable compounds in the development of new medications and therapies.
Used in Chemical Synthesis:
In the field of chemical synthesis, ACETOPHENONEO-BENZOYLOXIME is used as a versatile building block for the creation of various organic compounds. Its unique structure enables it to participate in a range of reactions, making it a valuable asset in the synthesis of complex molecules and materials.
ACETOPHENONEO-BENZOYLOXIME is used as a building block for [application type] in the synthesis of complex organic compounds. Its ability to undergo various chemical reactions allows it to be a key component in the development of new materials and products across different industries.

InChI:InChI=1/C15H13NO2/c1-12(13-8-4-2-5-9-13)16-18-15(17)14-10-6-3-7-11-14/h2-11H,1H3/b16-12+

Upstream product

• 613-91-2 acetophenone oxime 
• 98-88-4 benzoyl chloride 
• 959-22-8 p-nitrophenylbenzoate 
• 42331-33-9 acetophenone oximate anion 
• 94-36-0 dibenzoyl peroxide 
• 65-85-0 benzoic acid 
• 98-86-2 acetophenone 

Downstream Products

• 14688-28-9 (3,5-diphenylisoxazol-4-yl)(phenyl)methanone 
• 103-84-4 Acetanilid 
• 93472-50-5 1-methyl-3,4-diphenylisoquinoline 
• 729-43-1 acetophenonazine 
• 1449487-50-6 8-methyl-3-(methylthio)-2-phenylimidazo[1,2-a]pyridine 
• 5000-95-3 3-(methylthio)-2-phenylimidazo[1,2-α]pyridine 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 3558-69-8 2,6-diphenylpyridine 
• 20826-48-6 (R)-N-(1-phenylethyl)benzamide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 40636-57-5 (αS)-α-methyl-N-(1-phenylethylidene)benzenemethanamine 
• 89103-78-6 (-)-(R)-N-(1-phenylethyl)-α-methylbenzylideneamine 
• 26274-35-1 2,4-diphenylpyridine 
• 1721-96-6 1-methyl-3-phenylisoquinoline 

Relevant academic research and scientific papers

Synthesis of Sterically Hindered Primary Amines by Concurrent Tandem Photoredox Catalysis

Primary amines are an important structural motif in active pharmaceutical ingredients (APIs) and intermediates thereof, as well as members of ligand libraries for either biological or catalytic applications. Many chemical methodologies exist for amine synthesis, but the direct synthesis of primary amines with a fully substituted α carbon center is an underdeveloped area. We report a method which utilizes photoredox catalysis to couple readily available O-benzoyl oximes with cyanoarenes to synthesize primary amines with fully substituted α-carbons. We also demonstrate that this method enables the synthesis of amines with α-trifluoromethyl functionality. Based on experimental and computational results, we propose a mechanism where the photocatalyst engages in concurrent tandem catalysis by reacting with the oxime as a triplet sensitizer in the first catalytic cycle and a reductant toward the cyanoarene in the second catalytic cycle to achieve the synthesis of hindered primary amines via heterocoupling of radicals from readily available oximes.

A novel synthesis of carboxylic acid oxime esters catalyzed by 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate

We describe a facile synthesis of carboxylic acid oxime esters in acetonitrile from the corresponding carboxylic acids and oximes catalyzed by 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate in the presence of triethylamine at room temperature under mild conditions.

Efficient and alternative approach for preparation of O-benzoyloximes using benzoyl peroxide

Benzoyl peroxide has been used as a mild and efficient reagent for the preparation of benzoyl ester of oxime in moderate to good yields. Copyright Taylor & Francis Group, LLC.

The Effect of Solvent on the α-Effect: Abnormal Nucleophilic Reactivity of Substituted Acetophenone Oximate Anions in Aqueous DMSO

The nucleophilic reactivity of substituted acetophenone oximate anions decreases with increasing base strengthening ability of the substituent, resulting in a positive Hammett ρ value in H2O containing 20 mole percent DMSO.

Reaction of Trimethylsilyl Azide with C=N-O Bond

Trimethylsilyl azide (TMSA) was reacted with an oxime ester or a Reissert salt in the presence of trimethylsilyl trifluoromethanesulfonate to give tetrazole derivative.The details of these reactions are examined.