146918-35-6

Basic information

• Product Name: Isoxazole, 3-(4-methoxyphenyl)-5-(4-nitrophenyl)-
• CAS NO: 146918-35-6
• Molecular Formula: C16H12N2O4
• Molecular Weight: 296.282
• Mol File: 146918-35-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Isoxazole, 3-(4-methoxyphenyl)-5-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 3-(4-methoxyphenyl)-5-(4-nitrophenyl)-(146918-35-6)
• EPA Substance Registry System: Isoxazole, 3-(4-methoxyphenyl)-5-(4-nitrophenyl)-(146918-35-6)

Safety Data

• Hazardous Substances Data: 146918-35-6(Hazardous Substances Data)

Upstream product

• 38502-65-7 1-(4-nitrophenyl)-3-(4-methoxyphenyl)propane-1,3-dione 
• 100-19-6 (4-nitrophenyl)ethanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 51250-79-4 3-(4-methoxy-phenyl)-5-(4-nitro-phenyl)-4,5-dihydro-isoxazole 
• 123-11-5 4-methoxy-benzaldehyde 
• 3717-21-3 p-methoxyl benzaldoxime 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 

Downstream Products

• 748771-27-9 4-(5-(4-nitrophenyl)isoxazol-3-yl)phenol 

Relevant articles and documents

Synthesis of 3,5-diarylisoxazoles under solvent-free conditions using iodobenzene diacetate

A simple and efficient method has been developed for conversion of chalcone oximes to 3,5-diaryl isoxazoles in excellent yields under solvent-free conditions. The synthesized compounds were characterized by infrared spectroscopy, 1H NMR, 13C NMR and HRMS.

Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists

A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. In add