147034-01-3

Basic information

• Product Name: (2,5-dibroMophenyl)Methanol
• Synonyms: (2,5-dibroMophenyl)Methanol;2,5-Dibromobenzyl alcohol;Benzenemethanol, 2,5-dibromo-
• CAS NO: 147034-01-3
• Molecular Formula: C₇H₆Br₂O
• Molecular Weight: 265.92994
• Mol File: 147034-01-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 322.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.960±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.87±0.10(Predicted)
• CAS DataBase Reference: (2,5-dibroMophenyl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2,5-dibroMophenyl)Methanol(147034-01-3)
• EPA Substance Registry System: (2,5-dibroMophenyl)Methanol(147034-01-3)

Safety Data

• Hazardous Substances Data: 147034-01-3(Hazardous Substances Data)

Usage

General Description

(2,5-dibromophenyl)methanol is a chemical compound with the molecular formula C7H6Br2O. It is a white to light yellow solid that is used in various chemical reactions and as a building block for the synthesis of other compounds. This chemical is a brominated derivative of phenylmethanol and is commonly used in the pharmaceutical and agrochemical industries. It is a versatile compound that can undergo various chemical reactions to produce a wide range of derivatives, making it an important intermediate in organic synthesis. Additionally, it is used as a reagent in the preparation of various pharmaceuticals and other chemical products.

Upstream product

• 76008-76-9 2,5-dibromobenzoic acid ethyl ester 
• 57381-43-8 2,5-dibromobenzoic acid methyl ester 
• 610-71-9 2,5-dibromobenzoic acid 
• 111-25-1 1-bromo-hexane 
• 74553-29-0 2,5-dibromobenzaldehyde 
• 147033-99-6 2,5-dibromophenylmethylene diacetate 
• 615-59-8 1,4-dibromo-2-methylbenzene 

Downstream Products

• 1059111-41-9 C₁₆H₂₆Br₂OSi 
• 136105-40-3 1,4-dibromo-2-(bromomethyl)benzene 
• 168759-64-6 7-bromoisochroman-4-one 
• 74533-21-4 2-(2,5-dibromophenyl)acetonitrile 
• 203314-28-7 2-(2,5-dibromophenyl)-acetic acid 
• 203314-51-6 (2,5-dibromo-phenyl)-acetyl chloride 
• 642091-49-4 2,5-dibromobenzyl chloride 
• 74553-29-0 2,5-dibromobenzaldehyde 

Relevant articles and documents

Synthesis of 2,5-dibromobenzaldehyde and its reaction with hexylmagnesium bromide

2,5-Dibromobenzaldehyde (3) is synthesized by the oxidation of 2,5-dibromotoluene (1) via 2,5-dibromobenzylidene diacetate (2). Grignard reaction of hexylmagnesium bromide with 2 gives the normal addition product, 2,5-dibromo-α-hexylbenzyl alcohol (5) and

ALDOSTERONE SYNTHASE INHIBITORS

The present invention relates to compounds of the formulas (IA) and (IB) and pharmaceutically acceptable salts thereof, wherein A and R1 - R6, are as defined herein. The invention also relates to pharmaceutical compositions comprisin

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and irradiation. They have been implicated in the pathology of a variety of different diseases with an inflammatory component including asthma, stroke, Alzheimer's disease, and type 2 diabetes mellitus. In this work, high-throughput screening identified a JNK inhibitor with an excellent kinase selectivity profile. Using X-ray crystallography and biochemical screening to guide our lead optimization, we prepared compounds with inhibitory potencies in the low-double-digit nanomolar range, activity in whole cells, and pharmacokinetics suitable for in vivo use. The new compounds were over 1000-fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38α, and p38δ and showed little inhibitory activity against a panel of 74 kinases.