76008-76-9

Usage

Chemical compound

2,5-dibromobenzoic acid ethyl ester

Properties

white to off-white solid, melting point of 80-84°C, insoluble in water but soluble in organic solvents

Uses

intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds; reagent in organic synthesis for the preparation of esters and amides

Safety

potential irritant to skin, eyes, and respiratory system; should be handled with care in a laboratory setting

Upstream product

• 64-17-5 ethanol 
• 610-71-9 2,5-dibromobenzoic acid 
• 93-89-0 benzoic acid ethyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 24398-88-7 ethyl 3-bromobenzoate 

Downstream Products

• 136105-40-3 1,4-dibromo-2-(bromomethyl)benzene 
• 168759-64-6 7-bromoisochroman-4-one 
• 147034-01-3 (2,5-dibromophenyl)methanol 

Relevant academic research and scientific papers

Regio- and chemoselective C-H chlorination/bromination of electron-deficient arenes by weak coordination and study of relative directing-group abilities

It's all relative: A practical and efficient PdII-catalyzed regio- and chemoselective chlorination/bromination has been developed for the facile synthesis of a broad range of aromatic chlorides. The reaction demonstrates excellent reactivity, good functional-group tolerance, and high yields. A preliminary study was conducted to evaluate relative directing-group abilities of various functionalities. Copyright

Use of Potassium Bromate: Bromination of Halobenzenes and Halobenzoic Acids

Syntheses of bromo compounds by the bromination of halobenzenes and halobenzoic acids using potassium bromate under acidic condition have been discussed.