74533-21-4

Basic information

• Product Name: 2,5-DIBROMOBENZENE ACETONITRILE
• Synonyms: 2,5-DIBROMOBENZENE ACETONITRILE;2-(2,5-dibroMophenyl)acetonitrile;2,5-Dibromophenylacetonitrile
• CAS NO: 74533-21-4
• Molecular Formula: C₈H₅Br₂N
• Molecular Weight: 274.94
• Mol File: 74533-21-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 338.9°C at 760 mmHg
• Flash Point: 158.8°C
• Appearance: /
• Density: 1.857g/cm³
• Vapor Pressure: 9.5E-05mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,5-DIBROMOBENZENE ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIBROMOBENZENE ACETONITRILE(74533-21-4)
• EPA Substance Registry System: 2,5-DIBROMOBENZENE ACETONITRILE(74533-21-4)

Safety Data

• Hazardous Substances Data: 74533-21-4(Hazardous Substances Data)

Usage

General Description

2,5-DIBROMOBENZENE ACETONITRILE is a chemical compound with the molecular formula C8H5Br2N. It is a colorless to pale yellow liquid with a faint, almond-like odor. 2,5-DIBROMOBENZENE ACETONITRILE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a solvent and reagent in chemical reactions. 2,5-DIBROMOBENZENE ACETONITRILE is considered to be toxic if ingested or inhaled, and may cause skin and eye irritation upon contact. It should be handled with caution and appropriate protective measures.

InChI:InChI=1/C8H5Br2N/c9-7-1-2-8(10)6(5-7)3-4-11/h1-2,5H,3H2

Upstream product

• 642091-49-4 2,5-dibromobenzyl chloride 
• 106-37-6 1.4-dibromobenzene 
• 136105-40-3 1,4-dibromo-2-(bromomethyl)benzene 
• 610-71-9 2,5-dibromobenzoic acid 
• 151-50-8 potassium cyanide 
• 147034-01-3 (2,5-dibromophenyl)methanol 

Downstream Products

• 1350840-06-0 2-(2,5-dibromophenyl)-N-methoxyacetamide 
• 203314-51-6 (2,5-dibromo-phenyl)-acetyl chloride 
• 203314-28-7 2-(2,5-dibromophenyl)-acetic acid 

Relevant articles and documents

Synthetic method for 2,5-dibromophenylacetic acid

The invention discloses a synthetic method for an intermediate 2,5-dibromophenylacetic acid of an anti-HCV drug. According to the invention, dibromobenzene is used as a raw material and is subjected to chloromethylation, cyanidation and hydrolysis success

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and irradiation. They have been implicated in the pathology of a variety of different diseases with an inflammatory component including asthma, stroke, Alzheimer's disease, and type 2 diabetes mellitus. In this work, high-throughput screening identified a JNK inhibitor with an excellent kinase selectivity profile. Using X-ray crystallography and biochemical screening to guide our lead optimization, we prepared compounds with inhibitory potencies in the low-double-digit nanomolar range, activity in whole cells, and pharmacokinetics suitable for in vivo use. The new compounds were over 1000-fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38α, and p38δ and showed little inhibitory activity against a panel of 74 kinases.