147224-53-1

Basic information

• Product Name: (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate
• Synonyms: (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate
• CAS NO: 147224-53-1
• Molecular Weight: 267.715
• Mol File: 147224-53-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate(147224-53-1)
• EPA Substance Registry System: (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate(147224-53-1)

Safety Data

• Hazardous Substances Data: 147224-53-1(Hazardous Substances Data)

Upstream product

• 188635-61-2 (R)-3-(4-Chloro-phenyl)-4-iodo-butyric acid ethyl ester 
• 26717-54-4 β-(4-chlorophenyl)-γ-butyrolactone 
• 147224-51-9 β-(R)-(p-chlorophenyl)-γ-butyrolactone 
• 152714-07-3 3-(4-chlorophenyl)cyclobutanone 
• 1073-67-2 4-vinylbenzyl chloride 
• 114566-93-7 ethyl 4-bromo-3-(4-chlorophenyl)-2-butenoate 
• 99-91-2 para-chloroacetophenone 
• 81187-86-2 ethyl 3-(4-chlorophenyl)-2-butenoate 
• 21133-98-2 ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate 
• 537676-64-5 ethyl 4-azido-3-(4-chlorophenyl)-2-butenoate 

Downstream Products

• 188635-62-3 (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 

Relevant articles and documents

Enantioselective synthesis of (R)-(-)-baclofen via Ru(II)-BINAP catalyzed asymmetric hydrogenation

A short and efficient enantioselective synthesis of (R)-(-)-baclofen, a selective GABAB agonist has been described with an overall yield of 26% and 90% ee. Ru(II)-(S)-BINAP catalyzed asymmetric hydrogenations of C=C and C=O groups constitute the key steps in introducing stereogenic centers into the molecule.