188635-61-2

Upstream product

• 64-17-5 ethanol 
• 26717-54-4 β-(4-chlorophenyl)-γ-butyrolactone 
• 152714-07-3 3-(4-chlorophenyl)cyclobutanone 
• 1073-67-2 4-vinylbenzyl chloride 
• 147224-51-9 β-(R)-(p-chlorophenyl)-γ-butyrolactone 

Downstream Products

• 188635-62-3 (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 
• 147224-53-1 (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate 

Relevant academic research and scientific papers

A chemoenzymatic strategy for the synthesis of enantiopure (R)-(-)-baclofen

A seven-step enantioselective synthesis of (R)-(-)-baclofen 1 is described. The strategy developed involved as a key step, a microbiologically mediated Baeyer Villiger oxidation of the prochiral 3-(4'-chlorobenzyl)-cyclobutanone 3 which led to the optically pure (R)-(-)-4 lactone. This was further transformed throughout chemospecific reactions into the target molecule (R)-(-)-1.