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14733-22-3

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14733-22-3 Usage

Type of compound

Ketone

Molecular weight

289.41 g/mol

Physical form

White to off-white crystalline powder

Stability

Stable under normal storage conditions

Usage

Intermediate in the synthesis of various pharmaceuticals

Applications

Preparation of certain drugs, building block for chemical reactions in research

Industries

Pharmaceutical and chemical industries

Check Digit Verification of cas no

The CAS Registry Mumber 14733-22-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,3 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 14733-22:
(7*1)+(6*4)+(5*7)+(4*3)+(3*3)+(2*2)+(1*2)=93
93 % 10 = 3
So 14733-22-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H21NO2/c1-4-15(5-2)10-11-17-14-8-6-13(7-9-14)12(3)16/h6-9H,4-5,10-11H2,1-3H3

14733-22-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[4-[2-(diethylamino)ethoxy]phenyl]ethanone

1.2 Other means of identification

Product number -
Other names ACETOPHENONE,4'-(2-(DIETHYLAMINO)ETHOXY)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14733-22-3 SDS

14733-22-3Relevant articles and documents

Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease

Rampa, Angela,Bartolini, Manuela,Pruccoli, Letizia,Naldi, Marina,Iriepa, Isabel,Moraleda, Ignacio,Belluti, Federica,Gobbi, Silvia,Tarozzi, Andrea,Bisi, Alessandra

, (2018/08/17)

Alzheimer’s disease still represents an untreated multifaceted pathology, and drugs able to stop or reverse its progression are urgently needed. In this paper, a series of naturally inspired chalcone-based derivatives were designed as structural simplification of our previously reported benzofuran lead compound, aiming at targeting both acetyl (AChE)- and butyryl (BuChE) cholinesterases that, despite having been studied for years, still deserve considerable attention. In addition, the new compounds could also modulate different pathways involved in disease progression, due to the peculiar trans-α,β-unsaturated ketone in the chalcone framework. All molecules presented in this study were evaluated for cholinesterase inhibition on the human enzymes and for antioxidant and neuroprotective activities on a SH-SY5Y cell line. The results proved that almost all the new compounds were low micromolar inhibitors, showing different selectivity depending on the appended substituent; some of them were also effective antioxidant and neuroprotective agents. In particular, compound 4, endowed with dual AChE/BuChE inhibitory activity, was able to decrease ROS formation and increase GSH levels, resulting in enhanced antioxidant endogenous defense. Moreover, this compound also proved to counteract the neurotoxicity elicited by Aβ1–42 oligomers, showing a promising neuroprotective potential.

KINASE INHIBITORS

-

Page 65, (2008/06/13)

A compound of the general formula (I) or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated disease states using the compound of formula (I) is also de

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