147410-43-3Relevant articles and documents
A new synthesis of 3-substituted pyrrolidines using iron catalysed cross-coupling reactions and ring closing metathesis
?stergaard, Niels,Thoning Pedersen, Brian,Skj?rb?k, Niels,Veds?, Per,Begtrup, Mikael
, p. 1889 - 1891 (2002)
A series of 3-substituted N-Boc protected pyrrolidines have been prepared via iron catalysed cross-coupling between Boc protected N-allyl-N-(2-bromoallyl)amine 3 and organomagnesium compounds followed by ring closing metathesis and subsequent hydrogenatio
Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross Coupling
Ludwig, Jacob R.,Simmons, Eric M.,Wisniewski, Steven R.,Chirik, Paul J.
, (2020/11/02)
A cobalt-catalyzed method for the C(sp2)-C(sp3) Suzuki-Miyaura cross coupling of aryl boronic esters and alkyl bromides is described. Cobalt-ligand combinations were assayed with high-throughput experimentation, and cobalt(II) sources with trans-N,N′-dimethylcyclohexane-1,2-diamine (DMCyDA, L1) produced optimal yield and selectivity. The scope of this transformation encompassed steric and electronic diversity on the aryl boronate nucleophile as well as various levels of branching and synthetically valuable functionality on the electrophile. Radical trap experiments support the formation of electrophile-derived radicals during catalysis.
Iron- and cobalt-catalyzed arylation of azetidines, pyrrolidines, and piperidines with grignard reagents
Barr, Baptiste,Gonnard, Laurine,Campagne, Rmy,Reymond, Sbastien,Marin, Julien,Ciapetti, Paola,Brellier, Marie,Gurinot, Amandine,Cossy, Janine
supporting information, p. 6160 - 6163 (2015/01/16)
Iron- and cobalt-catalyzed cross-couplings between iodo-azetidines, -pyrrolidines, -piperidines, and Grignard reagents are disclosed. The reaction is efficient, cheap, chemoselective and tolerates a large variety of (hetero)aryl Grignard reagents.