1475-11-2Relevant articles and documents
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Park,Fuchs
, p. 93 (1957)
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Control of enantioselectivity in the enzymatic reduction of halogenated acetophenone analogs by substituent positions and sizes
Koesoema, Afifa Ayu,Standley, Daron M.,Ohshima, Shusuke,Tamura, Mayumi,Matsuda, Tomoko
supporting information, (2020/03/23)
We utilized acetophenone reductase from Geotrichum candidum NBRC 4597 (GcAPRD), wild type and Trp288Ala mutant, to reduce halogenated acetophenone analogs to their corresponding (S)- and (R)-alcohols beneficial as pharmaceutical intermediates. Reduction by wild type resulted in excellent (S)-enantioselectivity for all of the substrates tested. Meanwhile, reduction by Trp288Ala resulted in high (R)-enantioselectivity for the reduction of 4′ substituted acetophenone and 2′-trifluoromethylacetophenone. In addition to that, we were able to control the enantioselectivity of Trp288Ala by the positions and sizes of the halogen substituents.
Ambient-pressure hydrogenation of ketones and aldehydes by a metal-ligand bifunctional catalyst [Cp*Ir(2,2′-bpyO)(H2O)] without using base
Wang, Rongzhou,Qi, Jipeng,Yue, Yuancheng,Lian, Zhe,Xiao, Haibin,Zhuo, Shuping,Xing, Lingbao
, (2019/07/30)
An efficient catalytic system for hydrogenation of ketones and aldehydes using a Cp*Ir complex [Cp*Ir(2,2′-bpyO)(H2O)] bearing a bipyridine-based functional ligand as catalyst has been developed. A wide variety of secondary and primary alcohols were synthesized by the catalyzed hydrogenation of ketones and aldehydes under facile atmospheric-pressure without a base. The catalyst also displays an excellent chemoselectivity towards other carbonyl functionalities and unsaturated motifs. This catalytic system exhibits high activity for hydrogenation of ketones and aldehydes with H2 gas.
