14769-09-6

Upstream product

• 3937-94-8 2-(4-nitrophenyl)sulfonylacetic acid 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 3406-75-5 2-(4-nitrophenylthio)acetic acid 
• 1849-36-1 para-nitrobenzenethiol 
• 24067-17-2 4-nitrophenylboronic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 20455-07-6 p-nitrophenyl methanesulfonate 
• 6625-35-0 methyl 2-(4-nitrophenylsulfanyl)acetate 

Downstream Products

• 1314020-61-5 methyl 4-[(4-nitrophenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxylate 
• 1314020-67-1 4-[(4-azidophenyl)sulfonyl]-N-hydroxytetrahydro-2H-pyran-4-carboxamide 
• 1314020-68-2 N-hydroxy-4-({4-[(4-phenoxyphenyl)-1H-1,2,3-triazole-1-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide 
• 1314020-69-3 N-hydroxy-4-({4-[4-(4-methylphenyl)-1H-1,2,3-triazole-1-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide 
• 1314020-71-7 N-hydroxy-4-({4-[4-(4-pentylphenyl)-1H-1,2,3-triazole-1-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide 
• 1314020-72-8 N-hydroxy-4-({4-[4-(4-pentylbenzyl)-1H-1,2,3-triazole-1-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide 
• 1314020-73-9 N-hydroxy-4-{[4-(4-phenyl-1H-1,2,3-triazole-1-yl)phenyl]sulfonyl}tetrahydro-2H-pyran-4-carboxamide 
• 1314020-74-0 N-hydroxy-4-{[4-(4-biphenyl-4-yl-1H-1,2,3-triazole-1-yl)phenyl]sulfonyl}tetrahydro-2H-pyran-4-carboxamide 
• 1314020-75-1 N-hydroxy-4-({4-[4-(4-methoxyphenyl)-1H-1,2,3-triazole-1-yl]-phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide 
• 1314020-76-2 4-{[4-(4-butyl-1H-1,2,3-triazole-1-yl)phenyl]sulfonyl}-N-hydroxytetrahydro-2H-pyran-4-carboxamide 
• 1314020-77-3 N-hydroxy-4-[(4-{4-[((phenylsulfonyl)carbamoylamino)methyl]-1H-1,2,3-triazole-1-yl}phenyl)sulfonyl]-tetrahydro-2H-pyran-4-carboxamide 
• 1314020-78-4 N-hydroxy-4-({[4-(4-phenoxybenzyl)-1H-1,2,3-triazole-1-yl]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide 
• 4346-49-0 potassium p-nitrobenzenesulfonate 

Relevant academic research and scientific papers

Selective introduction of sulfo groups into aromatic nitro compounds

A new reaction has been found, viz. oxidative destruction of nitro-substituted sulfones ArSO2CH2CO2Me to give sulfonic acids ArSO3H on treatment with 70% HNO3; in addition, di(arylsulfonyl)furoxans ar

Synthesis of Sulfones via Ru(II)-Catalyzed Sulfination of Boronic Acids

Ruthenium(II) complexes catalyze the insertion of sulfur dioxide into (het)aryl and alkenyl boronic acids. The transmetalation-sulfination process proceeds with DABSO in the presence of 5 mol % RuCl2(PPh3)3 in methanol at 100 °C. The intermediate sulfinate salt can be quenched with various electrophiles such as alkyl halides, epoxides, Michael acceptors, and λ3-iodanes in moderate to good yields. The reported sulfone synthesis can be performed either as a direct one-pot or one-pot two-step procedure depending on the reactivity of the electrophile.

NOVEL AMINO-PHENYL-SULFONYL-ACETATE DERIVATIVES AND USE THEREOF

The present invention relates to a novel amino-phenyl-sulfonyl-acetate derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating diabetes comprising the same as an active ingredient.

Potent "clicked" MMP2 inhibitors: Synthesis, molecular modeling and biological exploration

A new series of MMP2 inhibitors is described, following a fragment-based drug design approach. One fragment containing an azide group and a well known hydroxamate Zinc Binding Group in a α-sulfone, α-tetrahydropyrane scaffold, has been synthesized. Water-

Sulfonyl Esters. V. A Preparation of Dichloromethyl Sulfones

α-Sulfonyl methyl esters have been chlorinated in the presence of base.Chlorination proceeds with accompanying demethoxycarbonylation to furnish dichloromethyl sulfones in good yields.

Applicability of Hammett Equation to Kinetics of Acid-catalysed Esterification of meta- and para-Substituted Phenylmercaptoacetic and Phenylsulphonylacetic Acids with Methanol

Rate constants have been determined for the acid-catalysed esterification of meta- and para-substituted phenylmercaptoacetic and phenylsulphonylacetic acids with methanol using hydrogen chloride as catalyst.The lower reactivities of phenylmercaptoacetic acids compared to those of the corresponding phenoxyacetic acids are discussed.