147729-57-5Relevant articles and documents
Anti-proliferative potential of triphenyl substituted pyrimidines against MDA-MB-231, HCT-116 and HT-29 cancer cell lines
Ranjan Dwivedi, Ashish,Kumar, Vijay,Kaur, Harmeet,Kumar, Naveen,Prakash Yadav, Ravi,Poduri, Ramarao,Baranwal, Somesh,Kumar, Vinod
supporting information, (2020/08/13)
A series of triphenyl substituted pyrimidines as analogous of colchicine and combretastatin A-4 was synthesized and evaluated for the antiproliferative potential. The compounds were screened against MDA-MB-231, HCT-116 and HT-29 cell lines using MTT assay. Most of the compounds displayed antiproliferative activity in low to sub micro molar concentration. Amongst the synthesized derivatives, compounds HK-2, HK-10 and HK-13 were found to be effective against all the three cancer cell lines. HK-2 exhibited IC50 values of 3.39 μM, 4.78 μM and 4.23 μM, HK-10 showed IC50 values of 0.81 μM, 5.89 μM, 4.96 μM and HK-13 showed IC50 values 3.24 μM, 4.93 μM and 4.73 μM against MDA-MB-231, HCT-116 and HT-29 cancer cell lines, respectively. HK-10 was found to be the most potent compound in the series with IC50 values of 0.81 μM against MDA-MB-231. In the cell cycle analysis, HK-2 and HK-10 showed cell arrest at G2/M phase of the cell cycle while HK-13 inhibited cell growth at the G1/G0 phase. All the three compounds showed cell death induced through apoptosis. In the docking studies, HK-2, HK-10 and HK-13 were found to fit well in the colchicine binding site of the tubulin. Some of the compounds in the current series were found to be promising against all the three cancer cell lines and may act as potent leads for further development.
One-pot synthesis of cinnamylideneacetophenones and their in vitro cytotoxicity in breast cancer cells
Weldon, David J.,Saulsbury, Marilyn D.,Goh, Joshua,Rowland, Leah,Campbell, Petreena,Robinson, Laijia,Miller, Calvin,Christian, Joshua,Amis, Louisa,Taylor, Nia,Dill, Cassandra,Davis Jr., Willie,Evans, Stanley L.,Brantley, Eileen
, p. 3381 - 3384 (2014/07/22)
A series of cinnamylideneacetophenones were synthesized via a modified Claisen-Schmidt condensation reaction and evaluated for cytotoxicity against breast cancer cells using the Alamar Blue assay. Derivatives 17 and 18 bearing a 2-nitro group on the B rin
Carbonylative heck reactions using CO generated ex situ in a two-chamber System
Hermange, Philippe,Gogsig, Thomas M.,Lindhardt, Anders T.,Taaning, Rolf H.,Skrydstrup, Troels
supporting information; experimental part, p. 2444 - 2447 (2011/07/09)
Chemical equations presented. A carbonylative Heck reaction of aryl iodides and styrene derivatives employing a two-chamber system using a stable, crystalline, and nontransition metal based carbon monoxide source is reported. By applying near-stoichiometr
