1482-70-8Relevant academic research and scientific papers
OXYSTEROLS AND METHODS OF USE THEREOF
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Paragraph 00233; 00235-00236, (2018/09/25)
Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, and R6, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
OXYSTEROLS AND METHODS OF USE THEREOF
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, (2018/05/16)
Compounds are provided according to Formula (A): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R5, R6, and RG are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS
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Page/Page column 188, (2016/05/24)
Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein (II), A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
Direct organocatalytic stereoselective transfer hydrogenation of conjugated olefins of steroids
Ramachary, Dhevalapally B.,Sakthidevi, Rajasekar,Reddy, P. Srinivasa
, p. 13497 - 13506 (2013/09/02)
Kinetically controlled and organocatalytic syn-selective transfer hydrogenation has been successfully demonstrated for the reduction of the enone functional group of various steroids. Herein, diastereoselective synthesis of many 5β-steroids have been reported through organocatalysis, which have broad medicinal and pharmaceutical applications. The mechanistic studies and the selectivity of the products clearly indicated that the catalyst 1b·d-CSA is mild enough to activate the various chiral cyclic enones through iminium ion formation during the organocatalytic transfer hydrogenations with Hantzsch ester 2a as a hydrogen source. Further, clear evidence for the selective formation of intermediate iminium species [I]+ have been characterized through on-line monitoring of controlled experiments by NMR and ESI-HRMS analyses.
Boar Taint Steroid Derivatives for Immunological Studies. Synthesis of 11α-Hydroxy-5α-androst-16-en-3-one and its Hemisuccinate
Turner, Alan B.,Leersum, Philip T. van
, p. 1653 - 1658 (2007/10/02)
5α-Androstane-3,11,17-trione has been converted into the title alcohol in five steps in an overall yield of 42 percent.Selective acetalization at C-3 allowed the use of vinyl iodide route for introduction of the double bond at C-16,17 by transformation of the 17-oxo group.Reduction of the intermediate 17-iodo-16-ene with sodium in ethanol took place with concomitant reduction of the 11-oxo group to the 11α-alcohol.Esterification with succinic anhydride gave the 11α-yl hemisuccinate.
Stereochemistry of the Palladium-catalyzed Hydrogenation of 3-Oxo-4-ene Steroids. V. A Kinetic Study in Basic and Acidic Media
Nishimura, Shigeo,Momma, Yasuhiro,Kawamura, Hideo,Shiota, Michio
, p. 780 - 783 (2007/10/02)
Effects of the β-methyl group at C-10 and some oxygen functions (=O, OH, OAc) at C-11, C-17, and C-20 on the rates of hydrogenation of 3-oxo-4-ene steroids have been studied with palladium catalyst in pyridine or THF/HBr as solvent.In contrast to the hydrogenation in pyridine, the rate in THF/HBr was greatly depressed by the presence of 10β-methyl group.The reactivity of the steroids was enhanced by the oxygen functions, in particular, by 11, 17-dioxo group.The effects of the substituents are discussed from a mechanistic consideration based on the obtained results.
