15375-19-6

Usage

Uses

Used in Pharmaceutical Industry:
5α-Androst-9(11)-ene-3,17-dione is used as an intermediate compound in the synthesis of various steroidal drugs for the pharmaceutical industry. Its presence as an impurity in testosterone production makes it a significant component in the development and manufacturing of androgen-related medications.
Used in Hormone Research:
In the field of endocrinology and hormone research, 5α-Androst-9(11)-ene-3,17-dione is utilized as a research compound to study the effects and mechanisms of testosterone and its conversion to 5α-dehydrotestosterone. This helps in understanding the role of androgens in male sexual differentiation and other physiological processes.
Used in Sports Medicine:
5α-Androst-9(11)-ene-3,17-dione may also be used in sports medicine as a compound for studying the effects of testosterone and its derivatives on athletic performance, muscle growth, and recovery. This can contribute to the development of therapies and supplements aimed at enhancing athletic performance while ensuring fair competition and adherence to anti-doping regulations.

Upstream product

• 1035-69-4 androst-4,9⁽¹¹⁾-dien-3,17-dione 
• 15375-18-5 5α-androst-9,11-en-17-on-3β-ol 
• 64-19-7 acetic acid 
• 846-46-8 androstanedione 
• 1816-85-9 11β-hydroxytestosterone 
• 7801-30-1 11β,17β-dihydroxy-5α-androstan-3-one 
• 90177-90-5 C₂₄H₃₄O₅ 
• 3461-74-3 3β-hydroxy-5α-androst-9(11)-en-17-one 3-acetate 
• 96626-96-9 3,17-bisethylenedioxy-5α-androstan-11β-ol 
• 32693-35-9 3,3;7,7-bisethylenedioxy-5α-androstane-11-one 
• 382-45-6 adrenosterone 
• 32326-39-9 3β,11α,17β-trihydroxy-5α-androstane 
• 3066-12-4 11α,17β-dihydroxyandrost-4-ene-3-one 
• 1429-06-7 5α-androstane-3,11,17-trione 

Relevant academic research and scientific papers

A direct radioimmunoassay for 5α-androstane-3α,17β-diol 17-glucuronide

Synthesis of the 11α-hemiglutaryl derivative of 5α-androstane-3α,17β-diol 17-glucuronide (androstanediol-17G) starting from androsta-4,9(11)-diene-3,17-dione through a 10-step sequence and the preparation of its bovine serum albumin conjugate is described.By using this conjugate, antiserum was raised in rabbits which proved to be very specific for androstanediol-17G.A direct radioimmunoassay using a double antibody procedure is described for the measurement of androstanediol-17G from plasma without prior chromatography.Keywords: direct radioimmunoassay; androstanediol-17glucuronide; tritium as tracer

SYNTHESIS OF A PRECURSOR FOR THE PREPARATION OF 9α,11α-TRITIATED 5α-ANDROSTANE-3α,17β-DIOL 17-GLUCURONIDE

Starting from 11β-hydroxytestosterone, we achieved the synthesis of a strategic precursor, C-19(11) unsaturated 5α-androstane-3α,17β-diol 17-glucuronide (9a), for the preparation of 9α,11α-tritiated 5α-androstane-3α,17β-diol 17-glucuronide.We optimized the reaction conditions for catalytic reduction employing hydrogen and subsequent base hydrolysis followed by purification on Amberlite XAD-2 resin to obtain the saturated 5α-androstane-3α,17β-diol 17-glucuronide.

Microbiological Transformations Part 7. Microbiological Transformations of A-nor- and A-homo-5α-androstane derivatives with the fungus Cunninghamella elegans.

The microbiological transformation of 17β-hydroxy-A-nor-5α-androstan-2-one, 17β-hydroxy-A-homo-5α-androstan-3-one and 5α-androstan-3,17-dione, by Cunninghamella elegans is dominated by 9α-hydroxylation whereas 17β-hydroxy-5α-androstan-3-one undergoes predominant 7α-monohydroxylation. 9α-Hydroxy-5α-androstane-3,17-dione and 9α-hydroxy-A-homo-5α-androstane-3,17-dione were synthesised by a sequence involving 11α-hydroxylation of the corresponding 3,17-diones by Aspergillus ochraceous.