1483-31-4Relevant articles and documents
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Seyferth,Shih
, p. 8464 (1973)
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Deaminative chlorination of aminoheterocycles
Ghiazza, Clément,Faber, Teresa,Gómez-Palomino, Alejandro,Cornella, Josep
, p. 78 - 84 (2021/12/23)
Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]
Synthesis, antibacterial evaluation and QSAR studies of 7-[4-(5-aryl-1,3,4-oxadiazole-2-yl)piperazinyl] quinolone derivatives
Kumar, Rajnish,Kumar, Ashwani,Jain, Sandip,Kaushik, Darpan
experimental part, p. 3543 - 3550 (2011/10/19)
A series of 7-[4-(5-aryl-1,3,4-oxadiazole-2-yl)piperazinyl] quinolones (I-XXI) were synthesized using an appropriate synthetic route and characterized by elemental and spectral analysis. The antibacterial activities of all the synthesized compounds were e
Synthesis of Some New 5-Aryl/Aryloxymethyl-2-Chloro-1,3,4-Oxadiazoles and their Oxadiazoloquinazolone Derivatives as Potential Pesticides
Singh, H.,Yadav, L. D. S.,Bhattacharya, B. K.
, p. 436 - 439 (2007/10/02)
Several 5-aryl/aryloxymethyl-2-chloro-1,3,4-oxadiazoles (III) have been prepared by treating 2-aryl/aryloxymethyl-Δ2-1,3,4-oxadizolin-5-ones (IIa) with POCl3/PCl5.The latter were prepared by cyclisation of their corresponding N-aroylaryloxyacet