148528-46-5

Basic information

• Product Name: dimethyl 1-benzyl-3,4-dimethoxypyrrole-2,5-dicarboxylate
• Synonyms: dimethyl 1-benzyl-3,4-dimethoxypyrrole-2,5-dicarboxylate
• CAS NO: 148528-46-5
• Molecular Weight: 333.341
• Mol File: 148528-46-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: dimethyl 1-benzyl-3,4-dimethoxypyrrole-2,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 1-benzyl-3,4-dimethoxypyrrole-2,5-dicarboxylate(148528-46-5)
• EPA Substance Registry System: dimethyl 1-benzyl-3,4-dimethoxypyrrole-2,5-dicarboxylate(148528-46-5)

Safety Data

• Hazardous Substances Data: 148528-46-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 6175-26-4 dimethyl 2,2′-(benzylazanediyl)diacetate 
• 1632-19-5 dimethyl 3,4-dihydroxy-1H-pyrrole-2,5-dicarboxylate 
• 6096-81-7 dimethyl iminodiacetate 
• 148528-45-4 dimethyl-1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 105935-07-7 3,4-dimethoxy-1H-pyrrole 
• 235434-26-1 1,1'-dibenzyl-3,4,3',4'-tetramethoxy-5,5'-diphenyl-1H,1'H-[2,2']bipyrrolyl 
• 235434-20-5 3,4,3',4'-tetramethoxy-5,5'-diphenyl-1H,1'H-[2,2']bipyrrolyl 
• 235434-23-8 1-benzyl-3,4-dimethoxy-5-phenyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 235434-24-9 1-benzyl-3,4-dimethoxy-5-phenyl-1H-pyrrole-2-carboxylic acid 
• 235434-25-0 1-benzyl-2-iodo-3,4-dimethoxy-5-phenyl-1H-pyrrole 
• 235434-22-7 1-benzyl-5-iodo-3,4-dimethoxy-1H-pyrrole-2-carboxylic acid methyl ester 
• 235434-21-6 1-benzyl-3,4-dimethoxy-1H-pyrrole-2,5-dicarboxylic acid monomethyl ester 

Relevant articles and documents

3,4-Dialkoxypyrroles and 2,3,7,8,12,13,17,18-octaalkoxyporphyrins

A five-step general synthesis of 3,4-dialkoxypyrroles 7c-f is described starting with the condensation of dimethyl N-benzyliminodiacetate (1 b) and diethyl oxalate to give dimethyl 1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate (2b), which is bis-O-alkylated to the corresponding 3,4-diethers 3c-g. Pyrrole N-benzyl cleavage followed by ester hydrolysis and decarboxylation leads to 7c-f in 10-50% overall yield. Pyrroles 7c-f react with formaldehyde or benzaldehydes to give meso-H- (8a-d) or meso-tetraaryloctaalkoxyporphyrins 9a-g in moderate yields.