148901-68-2Relevant articles and documents
Synthesis method of (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein
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Paragraph 0039; 0042; 0045; 0048, (2017/08/29)
The invention relates to a synthesis technology of pharmaceutical chemicals and particularly relates to a synthesis technology of (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein. (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-2-ethyl acrylate is taken as a raw material, and is thoroughly reduced into allyl alcohol through hydroboron, (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein is synthesized through DMSO oxidation, reaction conditions are optimized, and the yield of the (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein reaches over 95%. The method is simple in operation step, short in reaction period and high in conversion ratio; the required equipment is simple; the method is suitable for industrial massive production; the content of the produced (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein is greater than 99%; and the technical requirements of the market on the (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinoline]-2-acrolein are met.
PROCESS FOR PRODUCING QUINOLINE COMPOUND
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Page/Page column 6-7, (2008/06/13)
By a production method of a quinoline compound represented by the formula (I), which comprises reacting quinolinecarbaldehyde represented by the formula (II) with an imine compound represented by the formula (III) and then subjecting the resulting compoun
PROCESS FOR THE PREPARATION OF QUINOLYLPROPENAL
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, (2008/06/13)
3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enal is prepared in a high yield by reducing 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrite with Raney nickel either in the presence of formic acid and 0.25 to 1 part by volume of water per part by volume of formic acid or in the presence of both an amine salt of formic acid and an organic acid.