149286-06-6

Upstream product

• 374067-59-1 N-(2-bromo-2-phenylethyl)-4-methylbenzenesulfonamide 
• 127-09-3 sodium acetate 
• 24395-14-0 N-(p-tolylsulfonyl)-2-phenylaziridine 
• 108-24-7 acetic anhydride 
• 100-42-5 styrene 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 70-55-3 toluene-4-sulfonamide 
• 64-19-7 acetic acid 

Relevant academic research and scientific papers

N-heterocyclic carbene: An efficient catalyst for the ring-opening reaction of aziridine with acid anhydride

A N-heterocyclic carbene serves as an efficient catalyst for the regioselective ring-opening reactions of aziridines in the presence of acid anhydrides to afford the desired products in good to excellent yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Organocatalysis by an aprotic imidazolium zwitterion: Regioselective ring-opening of aziridines and applicable to gram scale synthesis

An imidazole-based zwitterionic-salt, 4-(3-methylimidazolium)butane sulfonate (MBS), has been found to be an efficient organocatalyst for aziridine ring-opening regioselectively by various nucleophiles like indoles, pyrroles, methanol, ethanol, acetic aci

A mild and regioselective ring-opening of aziridines with acid anhydride using TBD or PS-TBD as a catalyst

The ring-opening of N-tosylaziridines with various acid anhydrides catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding β-amino esters in excellent yields under mild reaction conditions. Polymer-supported catalyst,

Indium triflate-catalyzed ring opening of aziridines with carboxylic acids

Aziridines react smoothly with carboxylic acids in the presence of a catalytic amount of indium triflate at ambient temperature to afford the corresponding β-aminoacetates and benzoates in high yields with high regioselectivity.

Double Functionalization of Styrenes by Cu-Mediated Assisted Tandem Catalysis

The double functionalization of styrenes through Cu-mediated assisted tandem catalysis was developed. The reaction was initiated by Cu-catalyzed aziridination and the subsequent nucleophilic ring-opening, which was triggered by the addition of (NH4)2S2O8 as an oxidant of Cu-catalyst to form a variety of C–C and C–X bonds. The expansion to three contiguous catalytic cycles led to the synthesis of functionalized indolines by one-pot operation.

Rhodium-Catalyzed Alkene Difunctionalization with Nitrenes

The RhII-catalyzed oxyamination and diamination of alkenes generate 1,2-amino alcohols and 1,2-diamines, respectively, in good to excellent yields and with complete regiocontrol. In the case of diamination, the intramolecular reaction provides

A mild, rapid and highly regioselective ring-opening of epoxides and aziridines with acetic anhydride under solvent-free conditions using ammonium-12-molybdophosphate

A highly regioselective ring opening of epoxides and aziridines can be carried out efficiently with acetic anhydride to form the acetates of the corresponding 1,2-diols and 2-amino-alcohols, respectively, using ammonium-12-molybdophosphate (AMP) as a heterogeneous catalyst, at room temperature, in the absence of solvent.

Tributylphosphine-catalyzed ring-opening reaction of epoxides and aziridines with acetic anhydride

Reactions of aziridines and epoxides with acetic anhydride catalyzed by an organophosphine provided the corresponding esters of β-amino alcohols and 1,2-diols in high yields, respectively.