149456-98-4

Basic information

• Product Name: MethanesulfonaMide, N-[4-[2-(forMylaMino)acetyl]-5-Methoxy-2-phenoxyphenyl]-
• Synonyms: MethanesulfonaMide, N-[4-[2-(forMylaMino)acetyl]-5-Methoxy-2-phenoxyphenyl]-;N-(2-(2-Methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide;Iguratimod Impurity 12
• CAS NO: 149456-98-4
• Molecular Formula: C₁₇H₁₈N₂O₆S
• Molecular Weight: 378.39962
• EINECS: -0
• Mol File: 149456-98-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 619.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.357±0.06 g/cm3(Predicted)
• PKA: 6.45±0.10(Predicted)
• CAS DataBase Reference: MethanesulfonaMide, N-[4-[2-(forMylaMino)acetyl]-5-Methoxy-2-phenoxyphenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: MethanesulfonaMide, N-[4-[2-(forMylaMino)acetyl]-5-Methoxy-2-phenoxyphenyl]-(149456-98-4)
• EPA Substance Registry System: MethanesulfonaMide, N-[4-[2-(forMylaMino)acetyl]-5-Methoxy-2-phenoxyphenyl]-(149456-98-4)

Safety Data

• Hazardous Substances Data: 149456-98-4(Hazardous Substances Data)

Usage

General Description

Methanesulfonamide, N-[4-[2-(formylamino)acetyl]-5-methoxy-2-phenoxyphenyl]- is a chemical compound that belongs to the class of sulfonamides. It is a derivative of N-acylarylamines, which have been studied for their potential biological activities. This specific compound has a molecular structure that includes a formylamino group, a methoxy group, and a phenoxyphenyl group, which may contribute to its chemical and pharmacological properties. Further research is necessary to determine the exact biological and pharmaceutical activities of this compound.

Upstream product

• 10535-67-8 trimethylacetic formic anhydride 
• 149436-41-9 α-amino-2-methoxy-4-methanesulfonamido-5-phenoxyacetophenone hydrochloride 
• 141-53-7 sodium formate 
• 3197-61-3 N-formylimidazole 
• 64-18-6 formic acid 
• 124-38-9 carbon dioxide 
• 108-95-2 phenol 
• 123664-84-6 N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 76838-72-7 5-methoxy-2-phenoxyaniline 
• 84594-95-6 5-methoxy-1-nitro-2-phenoxybenzene 

Downstream Products

• 123663-49-0 Iguratimod 
• 149457-03-4 α-formamido-2'-hydroxy-4'-methanesulfonamido-5'-phenoxyacetophenone 

Relevant articles and documents

Preparation method of iguratimod intermediate

The invention discloses a preparation method of an iguratimod intermediate. The preparation method comprises the following steps: by using formic acid as a starting raw material, subjecting formic acid to reacting with N,N-carbonyldiimidazole (CDI) via an

Effective Formylation of Amines with Carbon Dioxide and Diphenylsilane Catalyzed by Chelating bis(tzNHC) Rhodium Complexes

The reductive formylation of amines using CO2 and hydrosilanes is an attractive method for incorporating CO2 into valuable organic compounds. However, previous systems required either high catalyst loadings or high temperatures to achieve high efficiency, and the substrate scope was mostly limited to simple amines. To address these problems, a series of alkyl bridged chelating bis(NHC) rhodium complexes (NHC=N-heterocyclic carbene) have been synthesized and applied to the reductive formylation of amines using CO2 and Ph2SiH2. A rhodium-based bis(tzNHC) complex (tz=1,2,3-triazol-5-ylidene) was identified to be highly effective at a low catalyst loading and ambient temperature, and a wide substrate scope, including amines with reducible functional groups, were compatible. Beyond the norm: Rhodium complexes bearing a strong electron-donating bis(1,2,3-triazol-5-ylidene) ligand were found to be excellent catalysts for the reductive formylation of amines with CO2 and Ph2SiH2 at ambient temperature. The catalyst system possesses a broad substrate scope which tolerates a variety of reducible functional groups and is suitable for the synthesis of bioactive compounds. Tf=trifuoromethanesulfonyl.