391668-61-4

Basic information

• Product Name: tert-butyl (4-(benzyloxy)benzyl)carbamate
• Synonyms: tert-butyl (4-(benzyloxy)benzyl)carbamate
• CAS NO: 391668-61-4
• Molecular Weight: 313.397
• Mol File: 391668-61-4.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (4-(benzyloxy)benzyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-(benzyloxy)benzyl)carbamate(391668-61-4)
• EPA Substance Registry System: tert-butyl (4-(benzyloxy)benzyl)carbamate(391668-61-4)

Safety Data

• Hazardous Substances Data: 391668-61-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 13139-12-3 tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate 
• 696-60-6 4-aminomethylphenol 
• 100-39-0 benzyl bromide 
• 149505-94-2 tert-butyl (4-hydroxybenzyl)carbamate 

Downstream Products

• 22171-15-9 4-(benzyloxy)benzylamine 
• 149505-94-2 tert-butyl (4-hydroxybenzyl)carbamate 

Relevant articles and documents

Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme

Autotaxin (ATX), a glycoprotein (~125 kDa) isolated as an autocrine motility factor from melanoma cells, belongs to a seven-membered family of ectonucleotide pyrophosphatase/phosphodiesterase (ENPP), and exhibits lysophospholipase D activity. ATX is responsible for the hydrolysis of lysophosphatidylcholine (LPC) to produce the bioactive lipid lysophosphatidic acid (LPA), which is upregulated in a variety of pathological inflammatory conditions, including fibrosis, cancer, liver toxicity and thrombosis. Given its role in human disease, the ATX-LPA axis is an interesting target for therapy, and the development of novel potent ATX inhibitors is of great importance. In the present work a novel class of ATX inhibitors, optically active derivatives of 2-pyrrolidinone and pyrrolidine heterocycles were synthesized. Some of them exhibited interesting in vitro activity, namely the hydroxamic acid 16 (IC50 700 nM) and the carboxylic acid 40b (IC50 800 nM), while the boronic acid derivatives 3k (IC50 50 nM), 3l (IC50 120 nM), 3 m (IC50 180 nM) and 21 (IC50 35 nM) were found to be potent inhibitors of ATX.

N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS

Disclosed herein are substantially pure forms of the compounds of Formula (I), (II), (III), (IV) and (V), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer or ester thereof. Also disclosed are methods of inhibiting an activity of a serotonin receptor, methods inhibiting an activation of a serotonin receptor, and methods of alleviating or treating various disease conditions and side effects.

Medicine comprising dicyanopyridine derivative

Compounds having a high conductance-type of calcium-activated K channel opening effect and a smooth muscle relaxant effect for bladder based on the K-channel opening effect, which can be used in treating pollakiuria and urinary incontinence, are provided.

MEDICINE COMPRISING DICYANOPYRIDINE DERIVATIVE

Compounds having a high conductance-type of calcium-activated K channel opening effect and a smooth muscle relaxant effect for bladder based on the K-channel opening effect, which can be used in treating pollakiuria and urinary incontinence, are provided. 3,5-Dicyanopyridine derivatives or their salts.