149651-90-1Relevant academic research and scientific papers
Synthesis of ethyl 5-cyano-6-hydroxy-2-methyl-4-(1-naphthyl)-nicotinate
Zhou, Yongchang,Kijima, Tatsuro,Kuwahara, Shunsuke,Watanabe, Masataka,Izumi, Taeko
, p. 3757 - 3761 (2008)
A novel ethyl 5-cyano-6-hydroxy-2-methyl-4-(1-naphthyl)-nicotinate is successfully synthesized and the structure is determined by XRD, GC-MS analysis, element analysis and NMR spectroscopic in detail. A reaction mechanism for the reaction is proposed.
Construction of 2-pyridonesviaoxidative cyclization of enamides: access to Pechmann dye derivatives
Chithanna, Sivanna,Yang, Ding-Yah
, p. 1565 - 1574 (2021)
An efficient protocol for the construction of structurally diverse 2-pyridone derivatives from imines and α,β-unsaturated acid chlorides in a single operation is reported. The target compounds, including coumarin-8-oxoprotoberbine analogues and lamellarin G isomers, were preparedviathermal cyclization of thein situgenerated enamides followed by thermal dehydrogenation. The cyclization of enamides was achieved by the introduction of an electron-withdrawing group on the α-carbon of acid chlorides. This methodology allows quick access to polycyclic Pechmann dyesviarare double oxidative cyclizations of dienamides under mild conditions.
Nitrile and Non-nitrile Pyridine Products from the Reaction of 2-Cyano-3-(x-nitrophenyl)prop-2-enamides with Methyl 3-Oxobutanoate
O'Callaghan, Conor N.,McMurry, T. Brian H.,Draper, Sylvia M.,Champeil, Elise
, p. 2901 - 2932 (2007/10/03)
The reaction of 2-cyano-3-(x-nitrophenyl)prop-2-enamides with methyl 3-oxobutanoate affords methyl 4-aryl-3-cyano-6-methyl-2-oxo-1,2-dihydropyridine-5-carboxylates, methyl 4-aryl-5-cyano-2-hydroxy-2-methyl-6-oxopiperidine-3-carboxylates, methyl 4-aryl-3-carbamoyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyridine-5-carboxylates (the molecular structure of one of which has been confirmed by X-ray diffraction) and methyl 4-aryl-3-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-5-carboxylates.
