Synthesis and some conformational features of the 5'-deoxy-5'-methylphosphonate linked dimer, 5'-deoxy-5'-C-(phosphonomethyl)thymidin-3'-yl (thymidin-5'-yl)methylphosphonate [p(CH2)Tp(CH2)T]

Article abstract of DOI:10.1016/0040-4020(95)00131-Q

Efficient synthesis of the 5'-deoxy-5'-methylphosphonate linked thymidine dimer 11 [p(CH₂)Tp(CH₂)T] was developed via the 5'-deoxy-5'-C-(phosphonomethyl)-3'-silylated thymidine derivative 4 as a key intermediate. Conformational analy