1498-54-0

Basic information

• Product Name: DICHLORO N,N-DIETHYLPHOSPHORAMIDITE
• Synonyms: DIETHYLPHOSPHORAMIDIC DICHLORIDE;DICHLORO N,N-DIETHYLPHOSPHORAMIDITE;DIETHYLAMINEDICHLOROPHOSPHINE OXIDE;N,N-Diethyl-phosphoramid-dichlorid;N,N-diethyl-phosphoramidedichloride;dichlorophosphoryl(diethyl)amine;N-dichlorophosphoryl-N-ethylethanamine;N-dichlorophosphoryl-N-ethyl-ethanamine
• CAS NO: 1498-54-0
• Molecular Formula: C₄H₁₀Cl₂NOP
• Molecular Weight: 190.01
• Mol File: 1498-54-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: >93.3 °C
• Boiling Point: 220℃
• Flash Point: 81.2°C
• Appearance: /
• Density: 1.277g/cm³
• Vapor Pressure: 0.191mmHg at 25°C
• Refractive Index: 1.4640
• PKA: -6.11±0.70(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: DICHLORO N,N-DIETHYLPHOSPHORAMIDITE(CAS DataBase Reference)
• NIST Chemistry Reference: DICHLORO N,N-DIETHYLPHOSPHORAMIDITE(1498-54-0)
• EPA Substance Registry System: DICHLORO N,N-DIETHYLPHOSPHORAMIDITE(1498-54-0)

Safety Data

• RIDADR: UN3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 1498-54-0(Hazardous Substances Data)

Usage

General Description

Dichloro N,N-diethylphosphoramidite is a chemical compound with the molecular formula C6H16Cl2NOP. It is a phosphoramidite reagent used in the synthesis of oligonucleotides, which are short segments of DNA or RNA. DICHLORO N,N-DIETHYLPHOSPHORAMIDITE is commonly used in the solid phase oligonucleotide synthesis, where it serves as a phosphitylating reagent to activate the hydroxyl groups on the phosphoramidite linkers. This activation allows for the stepwise addition of nucleotide units in the synthesis of oligonucleotides. Dichloro N,N-diethylphosphoramidite is an important tool in the field of molecular biology and genetic research, facilitating the creation of custom-designed oligonucleotides for various applications.

InChI:InChI=1/C4H10Cl2NOP/c1-3-7(4-2)9(5,6)8/h3-4H2,1-2H3

Upstream product

• 5775-33-7 N-chlorodiethylamine 
• 1069-08-5 diethylphosphoramidous dichloride 
• 100521-59-3 B-Tris-dimethylamino-N-triethyl-borazol 
• 109-89-7 diethylamine 
• 660-68-4 diethyl amine hydrochloride 

Downstream Products

• 1907-75-1 Diethylamido-phosphorsaeure-bis-ethylenimid 
• 6148-39-6 Phosphorsaeure-bis-(isopropylamid)-diethylamid 
• 93973-59-2 N,N-diethyl-di(2-thienyl)phosphinic amide 
• 66850-41-7 2-Diethylamino-3-N-phenyl-1,2,3-λ⁵-oxazaphospholidine-2-one 
• 75840-56-1 2-(diethylamino)-5-methyl-3-phenyl-1,3,2-oxazaphospholidine 2-oxide 
• 129835-85-4 N,N-diethyl-P-(3,5-dimethyl-4-hydroxyphenyl)-phosphonamidic chloride 
• 6214-04-6 diphenyl diethylphosphoramidate 
• 53859-37-3 2-(Diethylamino)-2H-1,3,2-oxazaphosphorinan-2-oxid 
• 6141-85-1 Phosphorsaeure-bis-(butylamid)-diaethylamid 
• 793-64-6 Dithiophosphorsaeure-S,S-diphenylester-diaethylamid 
• 78149-86-7 diethyl-(2-oxo-6c-trifluoromethyl-2λ⁵-[1,3,2]oxazaphosphinan-2r-yl)-amine 
• 78149-86-7 2-(Diethylamino)tetrahydro-6-trifluormethyl-2H-1,3,2-oxazaphosphorin-2-oxid 
• 81403-28-3 phenyl N,N-diethylamido phosphorochloridate 
• 1084-11-3 bis(4-methylphenyl)phosphinic acid 

Relevant articles and documents

Synthesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads

An efficient and operationally simple method is developed for the syndesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads. In me reaction, polymer resin acts as a scavenger for HCl produced as by-product and desired product is distilled under vacuum. Reaction afforded N, N-dialkyl phosphoramidic dichloride in 3-4 hours with excellent yields from corresponding dialkylamine and phosphoryl chloride.

-

-

Kinetic resolution of hydroperoxides with enantiopure phosphines: Preparation of enantioenriched tertiary hydroperoxides

An efficient reductive kinetic resolution strategy capable of accessing optically active tertiary hydroperoxides is reported. Readily accessible tertiary hydroperoxides are resolved with commercially available (R)- or (S)-xylyl-PHANEPHOS with selectivity factors as large as 37. The resulting bis(phosphine oxide) can be recycled in high yields. The isolated mono(phosphine oxide) intermediate resolved hydroperoxides with the same selectivity as the parent bisphosphine. Copyright

Studies on chiral thiophosphoric acids and their derivatives 16. - The asymmetric cyclization of L-(+)-prolinol with (thio)phosphoro(-no)dichloridates

The cyclizations of L-(+)-prolinol 5 with (thio)phosphoro(-no)dichloridates 6 give 1,2,3-azaphosphaoxabicyclo[3.3.0]octanes 7 consisting of unequal amounts of diastereoisomers, eight pairs of which have been successfully resolved by silica gel column chromatography or recrystallization. The influences of reaction temperature, solvent and substrate concentration upon the asymmetric induction have also been investigated.