15020-99-2Relevant articles and documents
Palladium(II) complexes with highly basic imidazolin-2-imines and their reactivity toward small bio-molecules
Bogojeski, Jovana,Volbeda, Jeroen,Freytag, Matthias,Tamm, Matthias,Bugar?i?, ?ivadin D.
, p. 17346 - 17359 (2015)
A series of novel Pd(ii) complexes with chelating mono(imidazolin-2-imine) and bis(imidazolin-2-imine) ligands were synthesized. The crystal structures of [Pd(DMEAImiPr)Cl2] and [Pd(DPENImiPr)Cl2] were determined by X-ray diffraction analysis. The reactivity of the six Pd(ii) complexes, namely, [Pd(en)Cl2], [Pd(EAImiPr)Cl2], [Pd(DMEAImiPr)Cl2], [Pd(DPENImiPr)Cl2], [Pd(BLiPr)Cl2] and [Pd(DACH(ImiPr)2)Cl2], were investigated. Spectrophotometric acid-base titrations were performed to determine the pKa values of the coordinated water molecules in [Pd(en)(H2O)2]2+, [Pd(EAImiPr)(H2O)2]2+, [Pd(DMEAImiPr)(H2O)2]2+, [Pd(DPENImiPr)(H2O)2]2+, [Pd(BLiPr)(H2O)2]2+ and [Pd(DACH(ImiPr)2)(H2O)2]2+. The substitution of the chloride ligands in these complexes by TU, l-Met, l-His and Gly was studied under pseudo-first-order conditions as a function of the nucleophile concentration and temperature using stopped-flow techniques; the sulfur-donor nucleophiles have shown better reactivity than nitrogen-donor nucleophiles. The obtained results indicate that there is a clear correlation between the nature of the imidazolin-2-imine ligands and the acid-base characteristics and reactivity of the resulting Pd(ii) complexes; the order of reactivity of the investigated Pd(ii) complexes is: [Pd(en)Cl2] > [Pd(EAImiPr)Cl2] > [Pd(DMEAImiPr)Cl2] > [Pd(DPENImiPr)Cl2] > [Pd(BLiPr)Cl2] > [Pd(DACH(ImiPr)2)Cl2]. The solubility measurements revealed good solubility of the studied imidazolin-2-imine complexes in water, despite the fact that these Pd(ii) complexes are neutral complexes. Based on the performed studies, three unusual features of the novel imidazolin-2-imine Pd(ii) complexes are observed, that is, good solubility in water, very low reactivity and high pKa values. The coordination geometries around the palladium atoms are distorted square-planar; the [Pd(DMEAImiPr)Cl2] complex displays Pd-N distances of 2.013(2) and 2.076(2) ?, while the [Pd(DPENImiPr)Cl2] complex displays similar Pd-N distances of 2.034(4) and 2.038(3) ?. The studied systems are of interest because little is known about the substitution behavior of imidazolin-2-imine Pd(ii) complexes with bio-molecules under physiological conditions.
The metal-binding sites of glycose phosphates
Gilg, Kathrin,Mayer, Tobias,Ghaschghaie, Natascha,Kluefers, Peter
, p. 7934 - 7945 (2009)
In aqueous solution, the reducing sugar phosphates d-arabinose 5-phosphate, d-ribose 5-phosphate, d-fructose 1,6-bisphosphate, d-fructose 6-phosphate, d-glucose 6-phosphate and d-mannose 6-phosphate provide metal-binding sites at their glycose core on rea
Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms
Rakovi?, Ivana R.,Radojevi?, Ivana D.,Mladenovi?, Katarina G.,Popovska Jovi?i?, Biljana D.,Petrovi?, Sara,?anovi?, Petar P.,?omi?, Ljiljana R.,?anovi?, Predrag S.,Bogojeski, Jovana V.
, p. 1229 - 1242 (2019/01/03)
The antimicrobial and antioxidant activities, as well as the DNA-binding of four square-planar Pd(II) complexes, [Pd(terpy)Cl]+ (C1), [Pd(en)Cl2] (C2), [Pd(DMEAImi Pr)Cl2] (C3) and [Pd(dach)Cl2] (C4) (terpy = 2,2′:6′,2′′--terpyridine, en = ethylenediamine, dach = trans-1,2-diaminocyclohexane and DMEAImi Pr = N2-((1,3-dihydro-1,3-diisopropyl-4,5-dimethyl)-2H-imidazol-2-ylidene)-N1,N1-dimethyl-1,2-ethanediamine are reported. The antimicrobial activities of the Pd(II) complexes with the appropriate ligands were tested using the microdilution method against 18 strains of microorganisms, whereby the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) were determined. The antibiofilm activity of [Pd(terpy)Cl]+ and the corresponding ligand were determined on a formed biofilm. The intensity of antimicrobial activity varied depending on the type of microorganism and the tested compound. The C1 complex with the corresponding ligand demonstrated significantly greater overall antimicrobial activity than C2, C3 and C4. The antibacterial activity of the C1 complex was better than its antifungal activity that was overall greater than that of the positive control, fluconazole. The greatest sensitivity for C1 and L1 was with Penicillium italicum (MIC -1) among the fungi, and with Proteus mirabilis ATCC 12453 (MIC = 0.98 μg mL-1) among the tested bacteria. The tested compounds show low and moderate antibiofilm activity. The complexes showed weak antioxidant properties when tested using the DPPH (1,1-diphenyl-2--picrylhydrazyl) method. The interaction of the metal complexes C1–C4 with calf thymus DNA (CT-DNA) was further examined by absorption (UV–Vis) and emission spectral studies (EthBr displacement studies). Overall, the investigated complexes exhibited good DNA interaction ability.
Synthesis, Characterization, and Cytotoxicity of Palladium(II) Complexes with Diimine/Diamine and N-Carbonyl-L-Phenylalanine Dianion
Wang, Li-Wei,Liu, Si-Yuan,Wang, Jin-Jie,Peng, Wen,Li, Sheng-Hui,Zhou, Guo-Qiang,Qin, Xin-Ying,Wang, Shu-Xiang,Zhang, Jin-Chao
, p. 1049 - 1056 (2015/03/18)
Six palladium(II) complexes, [Pd(bipy)(Bzphe-N,O)] (I-a), [Pd(bipy)(p-Mbzphe-N,O)]·2H2O (I-b), [Pd(bipy)(p-Nbzphe-N,O)]·2H2O (I-c), [Pd(phen)(Bmined by X-ray diffraction. The cytotoxicity test indicates that the complexes exert cytot
