15020-99-2Relevant articles and documents
Palladium(II) complexes with highly basic imidazolin-2-imines and their reactivity toward small bio-molecules
Bogojeski, Jovana,Volbeda, Jeroen,Freytag, Matthias,Tamm, Matthias,Bugar?i?, ?ivadin D.
, p. 17346 - 17359 (2015)
A series of novel Pd(ii) complexes with chelating mono(imidazolin-2-imine) and bis(imidazolin-2-imine) ligands were synthesized. The crystal structures of [Pd(DMEAImiPr)Cl2] and [Pd(DPENImiPr)Cl2] were determined by X-ray diffraction analysis. The reactivity of the six Pd(ii) complexes, namely, [Pd(en)Cl2], [Pd(EAImiPr)Cl2], [Pd(DMEAImiPr)Cl2], [Pd(DPENImiPr)Cl2], [Pd(BLiPr)Cl2] and [Pd(DACH(ImiPr)2)Cl2], were investigated. Spectrophotometric acid-base titrations were performed to determine the pKa values of the coordinated water molecules in [Pd(en)(H2O)2]2+, [Pd(EAImiPr)(H2O)2]2+, [Pd(DMEAImiPr)(H2O)2]2+, [Pd(DPENImiPr)(H2O)2]2+, [Pd(BLiPr)(H2O)2]2+ and [Pd(DACH(ImiPr)2)(H2O)2]2+. The substitution of the chloride ligands in these complexes by TU, l-Met, l-His and Gly was studied under pseudo-first-order conditions as a function of the nucleophile concentration and temperature using stopped-flow techniques; the sulfur-donor nucleophiles have shown better reactivity than nitrogen-donor nucleophiles. The obtained results indicate that there is a clear correlation between the nature of the imidazolin-2-imine ligands and the acid-base characteristics and reactivity of the resulting Pd(ii) complexes; the order of reactivity of the investigated Pd(ii) complexes is: [Pd(en)Cl2] > [Pd(EAImiPr)Cl2] > [Pd(DMEAImiPr)Cl2] > [Pd(DPENImiPr)Cl2] > [Pd(BLiPr)Cl2] > [Pd(DACH(ImiPr)2)Cl2]. The solubility measurements revealed good solubility of the studied imidazolin-2-imine complexes in water, despite the fact that these Pd(ii) complexes are neutral complexes. Based on the performed studies, three unusual features of the novel imidazolin-2-imine Pd(ii) complexes are observed, that is, good solubility in water, very low reactivity and high pKa values. The coordination geometries around the palladium atoms are distorted square-planar; the [Pd(DMEAImiPr)Cl2] complex displays Pd-N distances of 2.013(2) and 2.076(2) ?, while the [Pd(DPENImiPr)Cl2] complex displays similar Pd-N distances of 2.034(4) and 2.038(3) ?. The studied systems are of interest because little is known about the substitution behavior of imidazolin-2-imine Pd(ii) complexes with bio-molecules under physiological conditions.
Hydrolytic species of the ion cis-diaqua(ethylenediamine) palladium (II) complex and of cis-dichloro (ethylenediamine) palladium (II): Fitting its equilibrium models in aqueous media with or without chloride ion
Tercero-Moreno,Matilla-Hernandez,Gonzalez-Garcia,Niclos-Gutierrez
, p. 23 - 29 (1996)
Thermodynamic data for equilibria involved in the overall hydrolytic process of the cis-[Pd(en) (H2O)2]2+ complex in the presence or absence of chloride ion are reported. All expected hydrolytic species are taken into account to calculate their formation constants and to fit the equilibrium model. The formation constants (log βpqr) of aqua and/or hydroxo complexes were obtained from E(H+) data of alkalimetric titrations of cis-[Pd(en)(H2O)2] (ClO4)2 solutions. The log βpqr values of chloro-containing complexes were obtained from E(H+) and E(Cl-) data pairs, taking into account the above log β data as fixed values. All formation constants were fitted by SUPERQUAD calculations: log βpqr for cis-aqua-hydroxo (pqr= 10-1, -6.68 (10)), di-μ-hydroxo (20-2, -7.758(4)), cis-dihydroxo (10-2, -14.523(4)), cis-dichloro (120, 5.24(1)), cis-chloro-aqua (110, 3.18(1)) and cis-chloro-hydroxo (11-1, -3.75(4)) species for I=0.15 mol dm-3 in NaClO4 and t=37°C. This constant set allows good simulation of experimental titration curves and is used to obtain a variety of species distribution diagrams.
The metal-binding sites of glycose phosphates
Gilg, Kathrin,Mayer, Tobias,Ghaschghaie, Natascha,Kluefers, Peter
, p. 7934 - 7945 (2009)
In aqueous solution, the reducing sugar phosphates d-arabinose 5-phosphate, d-ribose 5-phosphate, d-fructose 1,6-bisphosphate, d-fructose 6-phosphate, d-glucose 6-phosphate and d-mannose 6-phosphate provide metal-binding sites at their glycose core on rea
Amine-bridged binuclear complexes involving [Pd(ethylenediamine)(H2O)2]2+, 4,4'-bipiperidine and DNA constituents
Khalaf Alla, Perihan A.,Shoukry, Mohamed M.,Van Eldik, Rudi
, p. 2041 - 2053 (2015)
The complex formation equilibria in the reaction of [Pd(en)(H2O)2]2+ with 4,4'-bipiperidine (Bip) and DNA constituents such as inosine, inosine-5'-monophosphate, uracil, uridine, thymine, and thymidine were investigated at
Antimicrobial, antioxidant and DNA-binding studies of palladium(II) complexes with different chelate ligands containing nitrogen donor atoms
Rakovi?, Ivana R.,Radojevi?, Ivana D.,Mladenovi?, Katarina G.,Popovska Jovi?i?, Biljana D.,Petrovi?, Sara,?anovi?, Petar P.,?omi?, Ljiljana R.,?anovi?, Predrag S.,Bogojeski, Jovana V.
, p. 1229 - 1242 (2019/01/03)
The antimicrobial and antioxidant activities, as well as the DNA-binding of four square-planar Pd(II) complexes, [Pd(terpy)Cl]+ (C1), [Pd(en)Cl2] (C2), [Pd(DMEAImi Pr)Cl2] (C3) and [Pd(dach)Cl2] (C4) (terpy = 2,2′:6′,2′′--terpyridine, en = ethylenediamine, dach = trans-1,2-diaminocyclohexane and DMEAImi Pr = N2-((1,3-dihydro-1,3-diisopropyl-4,5-dimethyl)-2H-imidazol-2-ylidene)-N1,N1-dimethyl-1,2-ethanediamine are reported. The antimicrobial activities of the Pd(II) complexes with the appropriate ligands were tested using the microdilution method against 18 strains of microorganisms, whereby the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) were determined. The antibiofilm activity of [Pd(terpy)Cl]+ and the corresponding ligand were determined on a formed biofilm. The intensity of antimicrobial activity varied depending on the type of microorganism and the tested compound. The C1 complex with the corresponding ligand demonstrated significantly greater overall antimicrobial activity than C2, C3 and C4. The antibacterial activity of the C1 complex was better than its antifungal activity that was overall greater than that of the positive control, fluconazole. The greatest sensitivity for C1 and L1 was with Penicillium italicum (MIC -1) among the fungi, and with Proteus mirabilis ATCC 12453 (MIC = 0.98 μg mL-1) among the tested bacteria. The tested compounds show low and moderate antibiofilm activity. The complexes showed weak antioxidant properties when tested using the DPPH (1,1-diphenyl-2--picrylhydrazyl) method. The interaction of the metal complexes C1–C4 with calf thymus DNA (CT-DNA) was further examined by absorption (UV–Vis) and emission spectral studies (EthBr displacement studies). Overall, the investigated complexes exhibited good DNA interaction ability.
A chiroptical molecular sensor for ferrocene
Agnes, Marco,Nitti, Andrea,Vander Griend, Douglas A.,Dondi, Daniele,Merli, Daniele,Pasini, Dario
supporting information, p. 11492 - 11495 (2016/10/03)
A homochiral, square-shaped, D2 symmetrical nanosized metal-linked macrocycle is able to form stable complexes with ferrocene in polar solvents, with detection achieved by means of multiple outputs (optical/chiroptical spectroscopies and cyclic voltammetry). Selective sensing using chiroptical spectroscopy in the presence of interfering analytes is demonstrated.
Synthesis, Characterization, and Cytotoxicity of Palladium(II) Complexes with Diimine/Diamine and N-Carbonyl-L-Phenylalanine Dianion
Wang, Li-Wei,Liu, Si-Yuan,Wang, Jin-Jie,Peng, Wen,Li, Sheng-Hui,Zhou, Guo-Qiang,Qin, Xin-Ying,Wang, Shu-Xiang,Zhang, Jin-Chao
, p. 1049 - 1056 (2015/03/18)
Six palladium(II) complexes, [Pd(bipy)(Bzphe-N,O)] (I-a), [Pd(bipy)(p-Mbzphe-N,O)]·2H2O (I-b), [Pd(bipy)(p-Nbzphe-N,O)]·2H2O (I-c), [Pd(phen)(Bmined by X-ray diffraction. The cytotoxicity test indicates that the complexes exert cytot
Synthesis, characterization, and cytotoxicity of platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and diimine/diamine
Li, Luwei,Zhang, Jinchao,Ma, Lili,Zhang, Zhilei,Wang, Shuxiang,Li, Shenghui,Zhou, Guoqiang
, p. 638 - 649 (2013/05/22)
Eight new platinum(II)/palladium(II) complexes with 4-toluenesulfonyl-L- amino acid dianion and diimine/diamine ligands, [Pd(en)(Tsile)]·H 2O (1), [Pd(bipy)(Tsile)] (2), [Pd(bipy)(Tsthr)]·0.5H 2O (3), [Pd(phen)(Tsile)]·0.5H2O (4), [Pd(phen)(Tsthr)]·H2O (5), [Pd(bqu)(Tsthr)]·1.5H 2O (6), [Pt(en)(Tsser)] (7), and [Pt(en)(Tsphe)]·H 2O (8), have been synthesized and characterized by elemental analyses, 1H NMR and mass spectrometry. The crystal structure of 7 has been determined by X-ray diffraction. Cytotoxicities were tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and sulforhodamine B assays. The complexes exert cytotoxicity against HL-60, Bel-7402, BGC-823, and KB cell lines with 4 having the best cytotoxicity against HL-60, Bel-7402, and BGC-823 cell lines; the compounds are less cytotoxic than cisplatin.
Pd complexes with trans-chelating ligands composed of two pyridyl groups and rigid π-conjugated backbone
Jung, Miso,Suzaki, Yuji,Saito, Takashi,Shimada, Kyoichi,Osakada, Kohtaro
, p. 168 - 174 (2012/08/28)
1,2-Bis(2-pyridylethynyl)benzene derivatives, having two pyridyl groups and π-conjugated backbone, were prepared from the 1:2 Sonogashira reaction of 1,2-diiodobenzene with 2-alkynyl pyridines. The obtained ligands react with the palladium(II) complexes such as [PdCl2(cod)] and [PdCl 2(MeCN)2] to form the complexes with the ligands coordinated in a trans-chelating bidentate mode. The ligand obtained from 1,3-diiodobenzene and 2-alkynyl pyridine bridges two Pd(II) centers, yielding a dipalladium complex. A dichloropalladium complex with the trans-chelating ligand, containing two methoxy groups in the central arylene group, promotes coupling of phenyl lithium and of phenyl acetylene to yield the respective homo-coupling products. The ligand displacement reactions of {bis(2-pyridylethynyl)benzene}palladium(II) complex with phosphine and dinitrogen ligands, such as PPh3, dppe, dppb, en, tmeda, bpy and phen, takes place smoothly to release the trans-chelating ligand.
Synthesis, characterization and cytotoxic activity of palladium (II) dithiocarbamate complexes with α,ω-diamines
Montagner, Diego,Marzano, Cristina,Gandin, Valentina
, p. 574 - 580 (2011/11/06)
The polymeric [PdCl(dithiocarbamate)]n complexes, in which the ligand ion is dimethyldithiocarbamate (DMDT), pyrrolidine dithiocarbamate (PyDT, (CH2)4NCS2-) and sarcosine ethyl ester dithiocarbamate (ESDT, EtO2CCH2N(CH 3)CS2-), have been reacted with chelating diamines, like ethylenediamine (en) or 1,3-diaminopropane (dap) and long chain diamines, like 1,4-diaminobutane (dab) or 1,7-diaminoheptane (dah). The reaction products depend on either diamine chain length or molar ratio. By operating at PdCl(dithiocarbamate)/diamine molar ratio 1:1 chelating diamines yielded the ionic [Pd(dithiocarbamate)(diamine)]Cl species (diamine = en or dap), whereas with long chain diamines species of the type [Pd(dithiocarbamate)(diamine)] nCln (diamine = dab or dah) were obtained, in which each Pd(dithiocarbamate)+ unit binds to the NH2 group of two different molecules, in a network of bridging diamines. At molar ratio 1:0.5, the long chain diamines yielded the binuclear [Pd2Cl 2(dithiocarbamate)2(diamine)] complexes (diamine = dab or dah), whereas exchange reactions take place generally in the presence of en or dap. The reaction trend is described on the basis of IR and proton NMR spectra. The new dithiocarbamate complexes were preliminarily tested for their cytotoxicity on human cancer cells.
