90315-14-3Relevant articles and documents
A new efficient synthesis of ω-aminoalkylidene-1,1-bisphosphonate tetraethylesters
Gourves, Jean-Philippe,Couthon, Helene,Sturtz, Georges
, p. 219 - 229 (1998)
Bisphosphonates are interesting therapeutic agents in the management of bone diseases and since several years our laboratory has been developing the chemistry of 1,1-bisphosphonates. This paper describes an original synthesis of two aminoalkylidenebisphosphonates by first preparing the intermediate hydroxyalkylidenebisphosphonates which are transformed into amines via the azides.