150368-99-3

Upstream product

• 120943-70-6 dimethyl <2-(tert-butyldimethylsilyl)-2-oxoethyl>-phosphonate 
• 150368-97-1 (2R,3S,5S)-5-Benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-carbaldehyde 
• 27826-73-9 2,5-anhydro-D-glucitol 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 150369-02-1 (S)-3-[(2S,3S,5S)-5-Benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-butyric acid 
• 150369-03-2 (S)-3-[(2S,3S,5S)-5-Benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-thiobutyric acid S-phenyl ester 
• 150369-16-7 (S)-4-[(2S,3S,5S)-5-Benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-1-(triphenyl-λ⁵-phosphanylidene)-pentan-2-one 
• 150369-01-0 (S)-3-[(2S,3S,5S)-5-Benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-1-(tert-butyl-dimethyl-silanyl)-butan-1-one 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF HALICHONDRINS: ENANTIOSELECTIVE CONSTRUCTION OF A HOMOCHIRAL TETRACYCLIC KLMN-RING INTERMEDIATE FROM D-MANNITOL

An efficient strategy exploiting C2 symmetry and featuring diastereoselective conjugate addition of Li2Me2CuCN to a γ-alkoxy-α,β-unsaturated acylsilane and diastereoselective spiroketalization provides a key tetracyclic KLMN-ring intermediate for halichondrin B from D-mannitol.