TOTAL SYNTHESIS OF HALICHONDRINS: ENANTIOSELECTIVE CONSTRUCTION OF A HOMOCHIRAL TETRACYCLIC KLMN-RING INTERMEDIATE FROM D-MANNITOL

DOI: 10.1016/S0040-4039(00)73673-2

Source and publish data:

Tetrahedron Letters p. 3247 - 3250 (1993)

Update date:2022-07-29

Topics:

Authors:

DiFranco, Elso

Ravikumar, Vasulinga T.

Salomon, Robert G.

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Article abstract of DOI:10.1016/S0040-4039(00)73673-2

An efficient strategy exploiting C2 symmetry and featuring diastereoselective conjugate addition of Li2Me2CuCN to a γ-alkoxy-α,β-unsaturated acylsilane and diastereoselective spiroketalization provides a key tetracyclic KLMN-ring intermediate for halichondrin B from D-mannitol.

Full text of DOI:10.1016/S0040-4039(00)73673-2

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