150618-03-4

Upstream product

• 108957-20-6 (R)-N-(tert-butoxycarbonyl)-3-iodoalanine benzyl ester 
• 156017-41-3 [Difluoro-(4-iodo-phenyl)-methyl]-phosphonic acid diethyl ester 
• 94882-74-3 benzyl 2(S)-(tert-butoxycarbonylamino)-3-p-toluenesulfonylpropionate 
• 150618-08-9 (S)-2-tert-Butoxycarbonylamino-3-(4-chlorocarbonyl-phenyl)-propionic acid benzyl ester 
• 123993-20-4 N-tert.-butoxycarbonyl-(4-trifluoromethanesulfonyloxy)-L-phenylalanine benzyl ester 
• 150618-07-8 4-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-benzoic acid 
• 59524-02-6 N-tert-butoxycarbonyl-L-serine benzyl ester 
• 1711-02-0 4-iodobenzoic acid chloride 
• 156017-40-2 diethyl (4-iodobenzoyl)phosphonate 
• 150618-09-0 (S)-2-tert-Butoxycarbonylamino-3-[4-(diethoxy-phosphoranecarbonyl)-phenyl]-propionic acid benzyl ester 

Downstream Products

• 150618-10-3 (S)-2-Acetylamino-3-{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-propionic acid 
• 150618-11-4 (S)-2-Acetylamino-3-[4-(difluoro-phosphono-methyl)-phenyl]-propionic acid 
• 156017-45-7 (S)-2-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-3-{4-[(diethoxyphosphoryl)difluoromethyl]phenyl}propanoic acid 
• 150618-05-6 (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propanoic acid 

Relevant academic research and scientific papers

Facile syntheses of aryldifluorophosphonate building blocks

The copper-catalysed zinc phosphonate chemistry described by Yokomatsu and Shibuya can be used directly in the synthesis of phosphotyrosine analogue F2Pmp, and in entering the classical organometallic coupling repertoire via Stille and Suzuki-M

Enantioselective synthesis of N-Boc and N-Fmoc protected diethyl 4-phosphono(difluoromethyl)-L-phenylalanine; agents suitable for the solid-phase synthesis of peptides containing nonhydrolyzable analogues of O-phosphotyrosine

Enantioselective convergent syntheses of N-Boc and N-Fmoc protected diethyl 4-phosphono(difluoromethyl)-L-phenylalanine are reported.

Preparation of L-(Phosphonodifluoromethyl) phenylalanine derivatives as non-hydrolyzable mimetics of O-phosphotyrosine

N-t-BOC-L-(Phosphonodifluoromethyl)phenylalanine benzyl ester (1) was prepared in 5 steps from N-t-BOC-L-tyrosine benzyl eser O-triflate (4). Compound 1 was further converted to derivatives 2 and 3 which are potentially suitable for peptide synthesis. Ana