151213-42-2Relevant articles and documents
Moxifloxacin process for the preparation of intermediates (by machine translation)
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, (2016/11/07)
The invention discloses a kind of Moxifloxacin process for the preparation of intermediates, MXC-1 with tetrahydrofurfuroxy pyrrolizinone condensation of the first, longer and acrylamide reaction produce MXC-2, MXC -2 passes through the reduction reaction produce MXC-3, MXC -3 hydrogenation to obtain MXC-4, to obtain a target product last MXC divided; the method step brief, the operation is simple, and is suitable for industrial mass production. (by machine translation)
A novel synthesis of (4aS,7aS)-Octahydro-1H-pyrrolo[3,4-b]pyridine:An intermediate of Moxifloxacin Hydrochloride
Reddy, G. Prashanth,Bandichhor, Rakeshwar
, p. 8701 - 8707 (2013/11/06)
A novel synthesis of (4aS, 7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine (1) is demonstrated alongwith recovery and reuse of chiral auxiliary naproxen. Further to this alternative stereoselective reduction procedures on 6-benzyl-5H- pyrrolo[3,4-b]pyridine-5,7(6H)-dione 3 enabling the desired chirality in the nonane 1 is demonstrated.
PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS
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Page column 58, (2010/02/06)
The invention relates to the phenylaminopyrimidines of formula (I), wherein A, D, R1, R2, R3 and R4 are defined as in the description. The invention also relates to methods for producing said phenylaminopyrimidines and to their use for producing drugs for the treatment and/or the prophylaxis of diseases, especially cardiovascular diseases.