1515-83-9

Basic information

• Product Name: 1-(methoxymethyl)-4-nitrobenzene
• CAS NO: 1515-83-9
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.162
• Mol File: 1515-83-9.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 258.2°C at 760 mmHg
• Flash Point: 119.2°C
• Density: 1.19g/cm³
• Vapor Pressure: 0.0224mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 1-(methoxymethyl)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(methoxymethyl)-4-nitrobenzene(1515-83-9)
• EPA Substance Registry System: 1-(methoxymethyl)-4-nitrobenzene(1515-83-9)

Safety Data

• Hazardous Substances Data: 1515-83-9(Hazardous Substances Data)

Usage

General Description

1-(Methoxymethyl)-4-nitrobenzene, also known as p-nitrobenzyl methyl ether, is a chemical compound with the molecular formula C8H9NO3. It is a yellow crystalline solid with a molecular weight of 167.16 g/mol. 1-(methoxymethyl)-4-nitrobenzene is commonly used as a protecting group for alcohols in organic synthesis, as it can be easily removed using mild acidic conditions. It is also used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. Additionally, it has potential applications in the field of organic electronics and as a precursor for the synthesis of other organic compounds. Overall, 1-(methoxymethyl)-4-nitrobenzene is a versatile and useful chemical compound with diverse applications in various industries.

Upstream product

• 67-56-1 methanol 
• 100-14-1 4-nitrobenzyl chloride 
• 4264-48-6 2-phenyl-4-formyl-5-chlorothiazole 
• 4264-44-2 5-chloro-2-(4-nitro-phenyl)-thiazole-4-carbaldehyde 
• 3474-89-3 2-(p-Nitrophenyl)-4-formyl-thiazol 
• 27490-32-0 tributyl(methoxymethyl)stannane 
• 586-78-7 para-nitrophenyl bromide 
• 13238-16-9 dibenzylphosphine oxide 
• 619-73-8 4-nitrobenzyl chloride 
• 74-88-4 methyl iodide 
• 6214-19-3 methyl p-methoxybenzenesulfonate 
• 617-86-7 triethylsilane 
• 881-67-4 4-nitrobenzaldehyde dimethyl acetal 
• 1455-13-6 deuteromethanol 

Downstream Products

• 80936-82-9 4-methoxymethyl-phenylamine 
• 100143-75-7 N-(α-methoxy-4-nitrobenzyl)succinimide 
• 555-16-8 4-nitrobenzaldehdye 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 106-49-0 p-toluidine 
• 6631-86-3 S-(p-chlorophenyl) p-nitrothiobenzoate 
• 619-72-7 4-nitrobenzonitrile 
• 22868-34-4 2-(4-nitrophenyl)benzothiazole 
• 1314096-28-0 C₁₅H₁₇NO 
• 80936-64-7 benzoic acid-(4-methoxymethyl-anilide) 
• 1135-12-2 p-benzylaniline 
• 30090-17-6 4-isobutylaniline 
• 929908-22-5 N,N'-bis-(4-methoxymethyl-phenyl)-1,6,7,12-tetrachloro-3,4:9,10-perylene-diimide 
• 62-23-7 4-nitro-benzoic acid 

Relevant articles and documents

Different Patterns of Mutagenicity of Arenediazonium Ions in V79 Cells and Salmonella typhimurium TA102: Evidence for Different Mechanisms of Action

The edible mushroom Agaricus bisporus contains several arylhydrazines and arenediazonium ions that are genotoxins.The mechanism whereby arylhydrazines and arenediazonium ions are genotoxic is unknown and may be due to the arenediazonium ion itself or to a

Auto-Tandem Catalysis with Frustrated Lewis Pairs for Reductive Etherification of Aldehydes and Ketones

Herein we report that a single frustrated Lewis pair (FLP) catalyst can promote the reductive etherification of aldehydes and ketones. The reaction does not require an exogenous acid catalyst, but the combined action of FLP on H2, R-OH or H2O generates the required Br?nsted acid in a reversible, “turn on” manner. The method is not only a complementary metal-free reductive etherification, but also a niche procedure for ethers that would be either synthetically inconvenient or even intractable to access by alternative synthetic protocols.

A kinetic model for water reactivity (avoiding activities) for hydrolyses in aqueous mixtures - Selectivities for solvolyses of 4-substituted benzyl derivatives in alcohol-water mixtures

For solvolyses of various benzyl substrates in ethanol-water (EW) and methanol-water (MW) mixtures, product selectivities (S) are reported for chlorides at 75°C defined as follows using molar concentrations: S= ([ether product]/[alcohol product]) × ([water]/[alcohol solvent]). The results support earlier evidence that solvolyses of 4-nitrobenzyl substrates are S N2 processes, which are not susceptible to mechanistic changes over the whole range of solvents from water to alcohol. S values at 25 and/or 45°C in EW and MW, and additional kinetic data including kinetic solvent isotope effects (KSIE) are reported for solvolyses of 4-nitrobenzyl mesylate and tosylate. A kinetic model, explaining both rates and product, is proposed; a general medium effect due to solvent polarity is combined in one parameter with solvent effects on the nucleophilicity of the water and alcohol molecules acting as nucleophiles in SN2 reactions. According to this model, as alcohol is added to water the rate of reaction decreases due to a decrease in solvent polarity, but the nucleophilicity of water increases relative to alcohol. The availability of experimental rate and product data over the whole range of solvent compositions from alcohol to water, reveals limitations of alternative approaches using activities. Copyright