80936-82-9Relevant academic research and scientific papers
Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase
Xu, Xingjun,Kim, Hye-Sun,Chen, Wei-Min,Ma, Xiang,Correy, Galen J.,Banwell, Martin G.,Jackson, Colin J.,Willis, Anthony C.,Carr, Paul D.
, p. 4044 - 4053 (2017/07/28)
The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.
Chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers catalyzed by palladium-nickel bimetallic nanoparticles
Chen, Wenwen,Bao, Hailin,Wang, Dingsheng,Wang, Xinyan,Li, Yadong,Hu, Yuefei
, p. 9240 - 9244 (2015/11/27)
A highly efficient and chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers was developed by using a novel palladium-nickel bimetallic nanocatalyst. Since the catalytic selectivity was resulted from the synergistic effects between two metals rather than the traditional catalyst poisons, the hydrogenation proceeded smoothly under additive-free conditions. Thus, the work-up procedure was as simple as to recover the catalyst by a magnetic separation and then to evaporate the solvent.
OXAZOLIDINONE HYDROXAMIC ACID COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
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Page/Page column 159; 160, (2015/05/19)
This invention pertains generally to treating bacterial infections using organic compounds of Formula I. In certain aspects, the invention pertains to treating infections caused by Gram-negative bacteria. (I) wherein X, Y, R1, R2, R3, R4 and R5 and defined herein.
Fluorescent perylene diimide rotaxanes: Spectroscopic signatures of wheel-chromophore interactions
Baggerman, Jacob,Jagesar, Dhiredj C.,Vallee, Renaud A. L.,Hofkens, Johan,De Schryver, Frans C.,Schelhase, Franke,Voegtle, Fritz,Brouwer, Albert M.
, p. 1291 - 1299 (2007/10/03)
[2]- and [3]-rotaxanes with a tetraphenoxy perylene diimide core were synthesized. Hydrogen bonding between the wheel and the imide changes the optical properties of the perylene chromophore: the absorption and fluorescence spectra are red-shifted. The decay times of the rotaxanes are shorter in comparison with that of the axle. Single molecule fluorescence measurements reveal relatively narrow distributions of emission maxima and decay times. The averages are in agreement with ensemble measurements. The observed red shifts make the perylene diimide a suitable chromophore for sensing the position of the wheel on the axle.
IMIDAZOQUINOLINES AS LIPID KINASE INHIBITORS
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Page/Page column 59, (2008/06/13)
The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.
Indium metal as a reducing agent in organic synthesis
Pitts,Harrison,Moody
, p. 955 - 977 (2007/10/03)
The low first ionisation potential (5.8 eV) of indium coupled with its stability towards air and water, suggest that this metallic element should be a useful reducing agent for organic substrates. The use of indium metal for the reduction of C=N bonds in imines, the heterocyclic ring in benzo-fused nitrogen heterocycles, of oximes, nitro compounds and conjugated alkenes and the removal of 4-nitrobenzyl protecting groups is described. Thus the heterocyclic ring in quinolines, isoquinolines and quinoxalines is selectively reduced using indium metal in aqueous ethanolic ammonium chloride. Treatment of a range of aromatic nitro compounds under similar conditions results in selective reduction of the nitro groups; ester, nitrile, amide and halide substituents are unaffected. Likewise indium in aqueous ethanolic ammonium chloride is an effective method for the deprotection of 4-nitrobenzyl ethers and esters. Indium is also an effective reducing agent under non-aqueous conditions and α-oximino carbonyl compounds can be selectively reduced to the corresponding N-protected amine with indium powder, acetic acid in THF in the presence of acetic anhydride or di-tert-butyl dicarbonate. Conjugated alkenes are also reduced by indium in THF-acetic acid.
Indium as a reducing agent: Reduction of aromatic nitro groups
Moody, Christopher J.,Pitts, Michael R.
, p. 1028 - 1028 (2007/10/03)
Treatment of a range of aromatic nitro compounds with indium powder in aqueous ethanolic ammonium chloride results in selective reduction of the nitro groups; ester, nitrile, amide and halide substituents are unaffected.
Different Patterns of Mutagenicity of Arenediazonium Ions in V79 Cells and Salmonella typhimurium TA102: Evidence for Different Mechanisms of Action
Lawson, Terence,Gannett, Peter M.,Yau, Wai-Ming,Dalal, Nar S.,Toth, Bela
, p. 2627 - 2635 (2007/10/03)
The edible mushroom Agaricus bisporus contains several arylhydrazines and arenediazonium ions that are genotoxins.The mechanism whereby arylhydrazines and arenediazonium ions are genotoxic is unknown and may be due to the arenediazonium ion itself or to a
Oxidation of Aromatic Compounds. I. Oxidation of Methyl Derivatives of Nitrobenzene and Aniline in the System HSO3F-PbO2
Rudenko, A. P.,Korovina, N. S.,Aver'yanov, S. F.
, p. 1077 - 1083 (2007/10/03)
Low-temperature oxidation of methyl derivatives of nitrobenzene and aniline in the system HSO3F-PbO2 proceeds with intermediate formation of radical cations and results in replacement of hydrogen in one or two methyl groups or yields compounds of the diphenylmethane and biphenyl series.
