15171-72-9

Upstream product

• 764-41-0 1,4-dichloro-2-butene 
• 139-02-6 sodium phenoxide 
• 1476-11-5 Z-1,4-dichlorobutene 
• 584-08-7 potassium carbonate 
• 108-95-2 phenol 
• 110-57-6 trans-1,4-dichlorobut-2-ene 

Downstream Products

• 75983-90-3 methyl (E)-3-oxo-8-phenoxy-6-octenoate 
• 221662-25-5 (2E)-N-Allyl-N-benzyl-4-phenoxybut-2-en-1-amine 
• 82259-82-3 methyl 2-pentyl-3-oxo-8-phenoxy-6-octenoate 

Relevant academic research and scientific papers

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

PCT No. PCT/US96/20872 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23216 PCT Pub. Date Jul. 3, 1997Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.

DTBB-catalysed lithiation of 4-functionalised 1-chloro-2-butenes

The reaction of N,N-disubstituted (E)-4-amino-1-chloro-2-butenes 1 with an excess of lithium and a catalytic amount of DTBB in the presence of an electrophile [E + = Bu(t)CHO, PhCHO, Me2CO, (CH2)5CO, (c-C3H