15179-92-7

Upstream product

• 62-53-3 aniline 
• 623-47-2 propynoic acid ethyl ester 
• 34780-29-5 3-oxo-propionic acid ethyl ester 
• 140-88-5 ethyl acrylate 
• 64-19-7 acetic acid 

Downstream Products

• 861794-73-2 3-anilino-2-chloroacetyl-acrylic acid ethyl ester 
• 861582-77-6 4-hydroxy-1-phenyl-pyrrole-3-carboxylic acid 
• 65172-12-5 4-hydroxy-1-phenyl-pyrrole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

TBAI or KI-Promoted Oxidative Coupling of Enamines and N-Tosylhydrazine: An Unconventional Method toward 1,5- and 1,4,5-Substituted 1,2,3-Triazoles

A novel method for the synthesis of 1,5- and 1,4,5-substituted 1,2,3-triazoles has been reported. This approach is promoted by iodine-TBHP oxidation system using enamines and N-tosylhydrazine as materials, which avoid the dependence of traditional methods on azides and transition metals. Through this approach, various 1,5- and 1,4,5-substituted 1,2,3-triazoles were delivered in moderate to high yields. The mechanistic study indicated that an amino exchange would be involved in the reaction process. Moreover, the product methyl 1-(2-methoxyphenyl)-4-methyl-1H-1,2,3-triazole-5-carboxylate is a useful precursor to anti-influenza A agent, and further application research was conducted. (Figure presented.).

Transition-metal-free synthesis of β-trifluoromethylated enamines with trifluoromethanesulfinate

We have developed a transition-metal free trifluoromethylation protocol between enamines and CF3SO2Na. A wide range of β-trifluoromethyl substituted enamines were delivered in moderate to high yields with only E-configurations.

A facile one-pot domino reaction for the stereoselective synthesis of acryl derivatives promoted by Ca(OTf)2

A facile one-pot domino reaction for the stereoselective synthesis of acryl derivatives has been reported using alkaline earth catalyst [Ca(OTf)2]. Initially aryl amine reacts with ethyl propiolate to form β-enamino ester which further reacts w

Selective fluorescent sensor for mercury ions in aqueous media using a 1,4-dihydropyridine derivative

Novel 1,4-dihydropyridine (DHP) derivatives containing 3 carboxylic acid units are synthesized via cyclotrimerization of N-substituted β-aminoacrylates followed by basic hydrolysis of the triester. These DHP derivatives are readily soluble in aqueous media buffered at pH 8.0 and the solutions give blue fluorescent signals with quantum yields of 7-23%. One of these compounds, bearing a p-methoxyphenyl N-substituted group, shows specific fluorescent quenching with the mercuric ion (Hg2+). The fluorescent signal of the DHP derivative decays over a period of minutes to hours depending on the Hg2+ concentration, which implies that the sensing mechanism involves chemical reaction between the Hg2+ ion and the DHP compound. The 1H NMR and MS data suggest that Hg2+ mediates the oxidation of the DHP ring into a pyridinium ring. The event is useful for fluorescent detection of Hg2+ at the micromolar level within 30 min, with a detection limit of 0.2 μM in aqueous medium.

ENZYMATIC SYNTHESIS OF PROPARGYLAMIDES

A lipase (Candida cylindracea) catalyzed the reaction between ethyl propiolate and aromatic amines to afford propargylamides.