15190-12-2

Basic information

• Product Name: 2-(4-methoxyphenyl)-2-pyrrolidin-1-ylacetonitrile
• Synonyms: 2-(4-methoxyphenyl)-2-pyrrolidin-1-ylacetonitrile;2-Pyrrolizino-2-(4-methoxyphenyl)acetonitrile;α-(4-Methoxyphenyl)-1-pyrrolidineacetonitrile;α-Pyrrolizino-4-methoxybenzeneacetonitrile;alpha-(Pyrrolidin-1-yl)-4-methoxyphenylacetonitrile;ALPHA-(4-METHOXYPHENYL)-1-PYRROLIDINEACETONITRILE
• CAS NO: 15190-12-2
• Molecular Formula: C₁₃H₁₆N₂O
• Molecular Weight: 216.27894
• EINECS: 239-243-4
• Mol File: 15190-12-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 325.2°Cat760mmHg
• Flash Point: 150.4°C
• Appearance: /
• Density: 1.122g/cm³
• Vapor Pressure: 0.000234mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 2-(4-methoxyphenyl)-2-pyrrolidin-1-ylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-2-pyrrolidin-1-ylacetonitrile(15190-12-2)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-2-pyrrolidin-1-ylacetonitrile(15190-12-2)

Safety Data

• Hazardous Substances Data: 15190-12-2(Hazardous Substances Data)

Usage

General Description

2-(4-methoxyphenyl)-2-pyrrolidin-1-ylacetonitrile is a chemical compound that is also known by the trade name "Ethylphenidate." It is a psychoactive substance that belongs to the class of synthetic cathinones and acts as a psychostimulant. It is often used as a research chemical and has been reported to produce effects similar to those of the prescription medication methylphenidate (Ritalin). Its psychoactive effects include increased alertness, focus, and feelings of euphoria. However, it also has potential for abuse, and its long-term health effects are not well understood. It is important to handle and use this chemical with caution and under the guidance of a qualified professional.

InChI:InChI=1/C13H16N2O/c1-16-12-6-4-11(5-7-12)13(10-14)15-8-2-3-9-15/h4-7,13H,2-3,8-9H2,1H3

Upstream product

• 4625-58-5 Bis(1-pyrrolidinyl)acetonitril 
• 123-11-5 4-methoxy-benzaldehyde 
• 123-75-1 pyrrolidine 
• 33646-40-1 4-methoxymandelonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 147-85-3 L-proline 

Relevant articles and documents

Propylphosphonic anhydride (T3P) catalyzed one-pot synthesis of α-aminonitriles

Abstract The Strecker reaction was performed via a one-pot three component condensation of hetero aromatic/aromatic aldehydes, secondary amines and trimetylsilyl cyanide in the presence of propylphosphonic anhydride (T3P) to accomplish the corresponding α-aminonitriles. The main advantages of this method are very short reaction time and excellent yields.

The decarboxylative strecker reaction

α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.

One-pot, solvent-free synthesis of α-aminonitriles under catalysis by magnesium bromide ethyl etherate

A three-component, efficient, and facile procedure has been developed for the synthesis of α-aminonitriles from aldehydes, amines, and trimethylsilyl cyanide using a catalytic amount of magnesium bromide ethyl etherate in the absence of solvent. Rapid formation of products is observed at room temperature in a one-pot procedure under very mild conditions giving excellent yields of the title compounds.