1520087-48-2

Upstream product

• 7455-77-8 2-(4-chlorophenyl)-4(3H)-quinazolinone 
• 1679-18-1 4-Chlorophenylboronic acid 
• 607-68-1 2,4-dichloroquinazoline 
• 104-88-1 4-chlorobenzaldehyde 
• 62-53-3 aniline 
• 2894-51-1 2-amino-4'-chlorobenzophenone 
• 104-86-9 4-chlorobenzylamine 

Relevant academic research and scientific papers

Visible-Light-Induced Benzylic C-H Functionalization for the Synthesis of 2-Arylquinazolines

This work reports a mild and efficient approach for the synthesis of substituted quinazolines using 1-(2-aminoaryl)ethan-1-ones in conjunction with arylmethanamines as starting materials via visible-light-induced benzylic C–H functionalization. The reaction proceeded at room temperature with low catalyst loading and the reaction system was clean from beginning to end. Significantly, this method exhibited good tolerance even to free hydroxyl group and amino group contained in substrates.

Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions

A four-component procedure for the preparation of substituted quinazolines from anilines, aromatic aldehydes and ammonium iodide is described. The C-H bond ortho to the amino group in anilines was directly functionalized under metal-free conditions. Two a

Design, synthesis and molecular properties prediction of novel quinazoline derivatives as potent antibacterial agents

A novel series of compounds were synthesized by C-C bond formation of substituted quinazolinones (1) with substituted boronic acids (2) to get 2,4-disubstituted quinazoline (3a-3n) in good to excellent yields. The structures of the new compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral data. An antibacterial and antifungal activity screening results showed that compounds 3b, 3e, 3i and 3l possess excellent activity against Gram (+), Gram (-) bacteria (S. aureus, Klebsiella species, P. aeruginosa) compared to standard drugs. 3l, 3g and 3n showed better antifungal activity against A. nigeri and C. albicans organisms. In this investigation, the target compounds 3a-3n were subjected to in silico molecular properties prediction and drug likeness by employing Molinspiration (Molinspiration, 2014) and MolSoft (MolSoft, 2007) property explorer tool kits for predicting their high oral bioavailability.

Csp2-O and C-C Bond Formation via Pd-Catalyzed Coupling Reaction of 2,4-Dichloroquinazoline

(Chemical Equation Presented) An efficient palladium-catalyzed C-O and subsequent C-C bond formation of 2,4-dichloroquinazoline have been described. The designed strategy results in the synthesis of novel 2-arylated quinazolin-4-ones framework with various aryl/heteroaryl boronic acids in moderate to good yields along with 2,4-diarylated quinazolines. This methodology offers a direct transformation of aryl halides to aryl alcohols/ketone as well as the straight forward application to generate a wide variety of monoaryl and diaryl quinazoline.

Synthesis of 4-arylquinazolines by arylation of quinazolin-4-ones under mild conditions

An efficient route to 4-arylquinazolines via arylation of quinazolin-4-ones under mild condition is described. The reaction is carried out by the palladium-catalyzed coupling of quinazolin-4-ones with arylboronic acids in the presence of TsCl leading to 4-arylquinazolines in good to excellent yields. Georg Thieme Verlag Stuttgart New York.