15219-34-8

Basic information

• Product Name: OXALYL BROMIDE
• Synonyms: oxalyl bromide solution;OXALYL BROMO;Dibromoethanedione;Oxalic acid dibromide;Oxalyl dibromide;Oxalyl bromide,98%;Oxalyl broMide, 98% 25GR;Oxalyl broMide 97%
• CAS NO: 15219-34-8
• Molecular Formula: C₂Br₂O₂
• Molecular Weight: 215.83
• EINECS: 239-271-7
• Product Categories: Others;Oxidation;Synthetic Reagents
• Mol File: 15219-34-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: −19 °C(lit.)
• Boiling Point: 16-17 °C10 mm Hg(lit.)
• Flash Point: -19°C
• Appearance: Clear/Liquid
• Density: 1.517 g/mL at 25 °C
• Vapor Pressure: 16.8mmHg at 25°C
• Refractive Index: n20/D 1.522(lit.)
• Storage Temp.: Refrigerator (+4°C)
• BRN: 1744437
• CAS DataBase Reference: OXALYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: OXALYL BROMIDE(15219-34-8)
• EPA Substance Registry System: OXALYL BROMIDE(15219-34-8)

Safety Data

• Hazard Codes: C,T
• Statements: 23/24/25-34-40-29-20-14-37
• Safety Statements: 26-36/37/39-45-28-27
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 8-9
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 15219-34-8(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to yellow-green liquid

Uses

Different sources of media describe the Uses of 15219-34-8 differently. You can refer to the following data:
1. Used in synthetic applications of carbon-substituted iminium saltsReactant for:Synthesis of mutasynthons added to cultures of A. pretiosum for mutasynthetic generation of ansamitocin derivativesOxalic acid formation from hydroxyl radical substitutionsCyclization to produce CRF1 receptor antagonistsPreparation, optical and electrochemical studies of thiophene end capped olig(2,3-alkylthieno[3,4-b]pyrazine)Asymmetrical synthesis of glycosyl chlorides and bromides
2. Leptin from rat has been used:to check the effect of intranasal nerve growth factor (NGF) on NGF activity in the spinal cord of Sprague-Dawley ratsfor validation of labelling for leptin-bearing cells of Sprague-Dawley ratsto study the effect of leptin on STAT3 (signal transducer and activator of transcription 3) phosphorylation in neural population of Sprague-Dawley ratsto study leptin response towards chemoreflex in nucleus of the solitary tractin rats, to check the effect of association between leptin and neuronal nitric oxide pathway on penicillin-induced epileptiform activity

Biochem/physiol Actions

Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.Human and mouse leptin share ~84% sequence identity.

InChI:InChI=1/C2Br2O2/c3-1(5)2(4)6

Synthetic route

oxalyl dichloride (79-37-8) → Oxalyl bromide (15219-34-8)

Conditions	Yield
With trimethylsilyl bromide for 1.5h;	85%
With hydrogen bromide unter Kuehlung;

oxalic acid (144-62-7) → Oxalyl bromide (15219-34-8)

Conditions	Yield
With phosphorus pentabromide; phosphorus(V) oxybromide

oxalyl dichloride (79-37-8) + hydrogen bromide (10035-10-6, 12258-64-9) → Oxalyl bromide (15219-34-8)

acetylene dibromide (624-61-3) + ethanol (64-17-5) + oxygen → 1,1,2,2-tetrabromoethene (79-28-7) + Oxalyl bromide (15219-34-8) + ethyl dibromoacetate (617-33-4) + CO

Upstream product

• 79-37-8 oxalyl dichloride 
• 624-61-3 acetylene dibromide 
• 64-17-5 ethanol 
• 10035-10-6 hydrogen bromide 
• 144-62-7 oxalic acid 

Downstream Products

• 4254-32-4 indan-2-carboxylic acid methyl ester 
• 618-32-6 Benzoyl bromide 
• 10500-28-4 cinnamoyl bromide 
• 22535-03-1 phenylacetyl bromide 
• 593-95-3 carbonyl dibromide 
• 41712-14-5 indene-2-carboxylic acid 
• 636-82-8 cyclohexene-1-carboxylic acid 
• 104438-94-0 (4,5-Dihydro-4,5-dioxo-1,2-diphenyl-3-pyrrolyl)triphenylphosphonium-bromid 
• 1201-25-8 azulene-1-carboxylic acid 
• 119-61-9 benzophenone 
• 134-81-6 benzil 
• 4371-74-8 dodecylmalonic acid 
• 7726-95-6 bromine 
• 15719-64-9 methylammonium carbonate 

Related news

Vibronic spectra, ab initio calculations, and structures of conformationally non-rigid molecules of oxalyl halides in the ground and lowest excited electronic states – Part VI: OXALYL BROMIDE (cas 15219-34-8) (COBr)2 and summary07/27/2019

The structure of oxalyl bromide (COBr)2 in the ground and four lowest excited electronic states was theoretically investigated using the CASPT2/cc-pVTZ-DK method. Structural information obtained allowed the reassignment of the A˜1Au←X˜1Ag and a˜3Au←X˜1Ag vibronic absorption spectra. Generaliza...detailed

Relevant articles and documents

Element-organische Verbindungen; 9. Mitteilung. Synthese von Carbonsaeure-bromiden und Carbonsaeure-iodiden mit Hilfe von Halogentrimethylsilanen

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