5564-73-8

Usage

Uses

Used in Pharmaceutical Industry:
1-(DIMETHOXYMETHYL)PYRROLIDINE is used as a building block for the synthesis of various pharmaceuticals due to its ability to be incorporated into complex molecular structures, enhancing the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
1-(DIMETHOXYMETHYL)PYRROLIDINE is used as a precursor in the production of agrochemicals, contributing to the creation of effective compounds for pest and disease control in agriculture.
Used in Fine Chemicals Industry:
1-(DIMETHOXYMETHYL)PYRROLIDINE is utilized as a key intermediate in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, flavors, and specialty chemicals.
Used in Antimicrobial Applications:
1-(DIMETHOXYMETHYL)PYRROLIDINE is employed as an antimicrobial agent for its potential to inhibit the growth of harmful microorganisms, offering a valuable tool in the development of new antimicrobial products.
Used in Antifungal Applications:
1-(DIMETHOXYMETHYL)PYRROLIDINE is used as an antifungal agent, leveraging its properties to combat fungal infections and contribute to the development of antifungal medications and treatments.
Used in Anti-inflammatory Applications:
1-(DIMETHOXYMETHYL)PYRROLIDINE is utilized in the development of anti-inflammatory drugs, capitalizing on its potential to reduce inflammation and alleviate associated symptoms.

Upstream product

• 123-75-1 pyrrolidine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 3760-54-1 1-pyrrolidinecarboxaldehyde 
• 124-41-4 sodium methylate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 36805-85-3 methoxy-pyrrolidin-1-yl-acetonitrile 
• 102354-16-5 2-((E)-1-Phenyl-3-pyrrolidin-1-yl-allylidene)-malononitrile 
• 89984-39-4 (E)-2-Phenyl-3-pyrrolidin-1-yl-N-[1-pyrrolidin-1-yl-meth-(E)-ylidene]-thioacrylamide 
• 83590-83-4 1-(4-nitro-phenyl)-3-(1-pyrrolidinyl)-2-propen-1-one 
• 127099-72-3 C-(Tetramethyleneimino)methylidene-P-phenylphosphine 
• 57988-74-6 N²-tosyl-N¹,N¹-cyclobutylformamide 
• 1530-88-7 pyrrolidine-1-carbonitrile 
• 19055-93-7 1,3-diazepan-2-one 
• 32989-69-8 trans-2-nitro-β-pyrrolidinostyrene 
• 61293-32-1 1-[(E)-2-(5-methoxy-2-nitrophenyl)vinyl]pyrrolidine 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 1233691-38-7 1-(1,5-diphenylpenta-1,4-diyn-3-yl)pyrrolidine 
• 1280538-41-1 C₁₂H₁₃BrN₂O₂ 
• 89984-31-6 N,N-Tetramethylene-N'-phenylthioacetyl-formamidine hydroperchlorate 

Relevant academic research and scientific papers

DECITABINE ANALOGS FOR IMMUNOLOGICAL AND ONCOLOGICAL THERAPY

Novel N44-substituted decitabine analogs are disclosed that exhibit promising in vitro and in vivo therapeutic activity. These novel compounds were shown to be resistant to deamination via cytidine deaminase (CDA) metabolism and provide a unique pharmacokinetic profile versus decitabine, while retaining the ability to induce DNA demethylation in target cells. These novel compounds can be used for treating hematological cancers, as well for new therapeutic interventions, including bacterial or viral pneumonia, acute respiratory distress syndrome, pulmonary fibrosis, transplantation and checkpoint inhibitor-induced adverse events, including pneumonitis.

Copper-catalyzed coupling reaction of c-ome bonds adjacent to a nitrogen atom with terminal alkynes

(Figure presented) The cross coupling of the C-OMe bond adjacent to a nitrogen atom in dialkoxy-N,N-dialkylmethanamines with terminal alkynes was efficiently approached in the presence of copper catalyst under mild conditions to give 3-amino-1,4-diynes in good yields. The reaction is promoted by phosphine ligands and the chemistry provides a simple and efficient route to 3-amino-1,4-diynes. Importantly, the Michael addition occurred with as-prepared 3-amino-1,4-diynes to give the useful Michael-adducts containing tert-alkylamines in a very convenient way. Further studies revealed that (E)-1,5-diarylpent-1-en-4-yn-3-one was formed through the rearrangement by using the neutral alumina column, and the corresponding imine 2-(1,5-diphenylpent-2- en-4-ynylideneamino)ethanol was obtained in the presence of AgOTf.

COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS

The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activit

A spectroscopic investigation of donor-acceptor-substituted heptalenes

It is shown that the heptalene-4,5-dicarboxylates 5 react with their Me group at C(1) with N,N-dimethylformamide dimethyl acetal or other acetals of this type in N,N-dimethylformamide (DMF) to give the corresponding 1-[(E)-2-(N,N-dialkylamino)ethenyl]-sub

SYNTHESIS OF C-(N,N-DIALKYLAMINO)PHOSPHAALKENES

New C-(N,N-dialkylamino)phosphaalkenes were synthesized by the reaction of phenylphosphine with amidacetals.Such compounds were also synthesized by the reaction of bis(trimethylsilyl)phosphine with amidacetals.

1H Nuclear Magnetic Resonance Study of the Kinetics of the Reaction of N,N-Dialkylformamide Dimethyl Acetals with Secondary Amines

Rate constants and activation parameters (ΔG, ΔH, ΔS) for the reactions of N,N-dialkylformamide dimethyl acetals with four secondary amines have been estimated by 1H n.m.r. spectroscopy.The reactions are reversible and obey a second-order kinetic equation.Substitution of one methoxy group of the amide acetal by the amine entity is found to give ester aminals which are subject to decomposition (ΔG 92-103 kJ mol-1).A transamination reaction yields a new amide acetal at higher temperatures (ΔG 115 kJ mol-1).On the basis of the kinetic data, the mechanism of these reactions is discussed.