153334-59-9Relevant articles and documents
One-pot three-component process for the synthesis of substituted pyrano[2,3-c]pyrazoles catalyzed by nanostructured FSM-16-SO3H
Hashemi-Uderji, Somayeh,Abdollahi-Alibeik, Mohammad
, p. 1709 - 1719 (2018)
A three-component process for the one-pot synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles by the reaction of aldehydes, 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, and malononitrile in the presence of FSM-16-SO3/s
Sulfamic acid catalysed one-pot three-component condensation for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles
Shinde, Sandeep V.,Jadhav, Wamanrao N.,Kondre, Jeevan M.,Gampawar, Sumit V.,Karade, Nandkishor N.
, p. 278 - 279 (2008)
A clean and simple synthesis of 6-amino-4-aryl-3-methyl-1-phenyl-1,4- dihydropyrano[2,3-c]pyrazole-5-carbonitriles was accomplished in good to excellent yields via the one-pot three component condensation of 3-methyl-1-phenyl- 2-pyrazolin-5-one, an aromat
Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors
Murahari, Manikanta,Mahajan, Vivek,Neeladri, Sreenivasulu,Kumar, Maushmi S.,Mayur
, p. 583 - 597 (2019/02/24)
The design and synthesis of novel pyrazole based derivatives has been carried out using the ligand based approach like pharmacophore and QSAR modelling of reported pyrazoles from the available literature to investigate the chemical features that are essential for the design of selective and potent COX-2 inhibitors. Both pharmacophore and QSAR models with good statistical parameters were selected for the design of the lead molecule. Also by exploiting the chemical structures of selective and marketed COX-2 inhibitors, celecoxib and SC-558 were used in designing the molecules which are used in the treatment of inflammation and related disorders. The therapeutic action of the Non-Steroidal Anti-inflammatory Agents (NSAIDs) is based primarily on the COX-2 inhibition. With this background we have synthesized some azomethine derivatives of 3-methyl-1-substituted-4-phenyl-6-[{(1E)-phenylmethylene}amino]-1,4-dihydro pyrano[2,3-c]pyrazole-5-carbonitrile 6(a-o) and were characterized by 1HNMR, 13CNMR and Mass spectral techniques. All the synthesized pyrazole derivatives were tested for in vitro membrane stability property in both COX-1 & COX-2 inhibition studies and in vivo anti-inflammatory activity by carrageenan induced rat paw edema model. Among them, compound 6k showed very good activity by in vivo anti-inflammatory activity with 0.8575 mmol/kg as ED50. Similarly compounds 6m, 6o, 6i and 6h exhibited comparable anti-inflammatory activity to standard drugs. Also the active compounds were further screened for ulcerogenic activity and were found be safer with less ulcer index compared to the marketed drugs like aspirin, ibuprofen and celecoxib.
Synthesis and antimicrobial screening of pyrimidine annulated dihydropyrano[2, 3-c] pyrazole derivatives
Hegde, Hemant,Ahn, Chuljin,Waribam, Preeti,Shetty, Nitinkumar S.
, p. 87 - 92 (2018/04/02)
A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction
