153334-59-9

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 89-25-8 edaravone 
• 109-77-3 malononitrile 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 100-63-0 phenylhydrazine 
• 141-97-9 ethyl acetoacetate 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 2972-80-7 3,4-dimethoxybenzylidenemalononitrile 

Relevant academic research and scientific papers

One-pot three-component process for the synthesis of substituted pyrano[2,3-c]pyrazoles catalyzed by nanostructured FSM-16-SO3H

A three-component process for the one-pot synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles by the reaction of aldehydes, 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, and malononitrile in the presence of FSM-16-SO3/s

Three-component one-pot synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives in aqueous media

6-Amino-5-cyano-4-aryl-1,4-dihydropyrano[2,3-c]pyrazoles were synthesized by three-component reaction of aromatic aldehydes, malononitrile, and 3-methyl-1-phenyl-2-pyrazolin-5-one using triethylbenzylammonium chloride (TEBA) as catalyst in aqueous media.

Sulfamic acid catalysed one-pot three-component condensation for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles

A clean and simple synthesis of 6-amino-4-aryl-3-methyl-1-phenyl-1,4- dihydropyrano[2,3-c]pyrazole-5-carbonitriles was accomplished in good to excellent yields via the one-pot three component condensation of 3-methyl-1-phenyl- 2-pyrazolin-5-one, an aromat

Synthesis of 3-methyl-6-amino-5-cyano-4-aryl-1-phenyl-1,4-dihydropyrano [2,3-c]pyrazole catalysed by KF-montmorillonite

The reaction of substituted arylidenemalononitrilesand3-methyl-1-phenyl-2- pyrazolin-5-one in DMF in the presence of KF-montmorillonite provides a rapid synthesis of 3-methyl-6-amino-5-cyano-4-aryl-1-phenyl-1,4-dihydropyrano[2,3-c] pyrazole derivatives.

Preparation, characterization and catalytic application of molybdenum Schiff-base complex immobilized on silica-coated Fe3O4 as a reusable catalyst for the synthesis of pyranopyrazole derivatives

A recoverable molybdenum Schiff-base complex immobilized on silica-coated Fe3O4 nanoparticles was prepared and characterized. This superparamagntic nanocatalyst, which is separable using an external magnet, can be used as an efficien

Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors

The design and synthesis of novel pyrazole based derivatives has been carried out using the ligand based approach like pharmacophore and QSAR modelling of reported pyrazoles from the available literature to investigate the chemical features that are essential for the design of selective and potent COX-2 inhibitors. Both pharmacophore and QSAR models with good statistical parameters were selected for the design of the lead molecule. Also by exploiting the chemical structures of selective and marketed COX-2 inhibitors, celecoxib and SC-558 were used in designing the molecules which are used in the treatment of inflammation and related disorders. The therapeutic action of the Non-Steroidal Anti-inflammatory Agents (NSAIDs) is based primarily on the COX-2 inhibition. With this background we have synthesized some azomethine derivatives of 3-methyl-1-substituted-4-phenyl-6-[{(1E)-phenylmethylene}amino]-1,4-dihydro pyrano[2,3-c]pyrazole-5-carbonitrile 6(a-o) and were characterized by 1HNMR, 13CNMR and Mass spectral techniques. All the synthesized pyrazole derivatives were tested for in vitro membrane stability property in both COX-1 & COX-2 inhibition studies and in vivo anti-inflammatory activity by carrageenan induced rat paw edema model. Among them, compound 6k showed very good activity by in vivo anti-inflammatory activity with 0.8575 mmol/kg as ED50. Similarly compounds 6m, 6o, 6i and 6h exhibited comparable anti-inflammatory activity to standard drugs. Also the active compounds were further screened for ulcerogenic activity and were found be safer with less ulcer index compared to the marketed drugs like aspirin, ibuprofen and celecoxib.

Synthesis and antimicrobial screening of pyrimidine annulated dihydropyrano[2, 3-c] pyrazole derivatives

A series of pyrimidine annulated dihydropyrano[2, 3-c]pyrazole derivatives were synthesized and screened for their antimicrobial activity. The precursor, dihydropyrano[2, 3-c]pyrazole was synthesised under catalyst free condition using PEG-400 as reaction

Cinnamomum tamala leaf extract-mediated green synthesis of Ag nanoparticles and their use in pyranopyrazles synthesis

A novel, biochemical, and eco-friendly method has been developed for the synthesis of Ag nanoparticles using an aqueous leaf extract of readily accessible Cinnamomum tamala as reducing and stabilizing agents. These Ag nanoparticles were used to catalyze t

Silica-bonded N-propylpiperazine sodium n-propionate as recyclable catalyst for synthesis of 4H-pyran derivatives

Silica-bonded N-propylpiperazine sodium n-propionate (SBPPSP) was found to act as an efficient solid base for the preparation of a series of 4H-benzo[b]pyran derivatives. SBPPSP was used as a recyclable heterogeneous solid base catalyst for the synthesis

A simple route for the synthesis of pyrano[2,3-c]pyrazole and pyridine-2-one derivatives

A series of pyrano[2,3-c]pyrazoles and pyridine-2-ones were prepared through the ternary condensation of aldehydes with malononitrile and 3-methyl-1-phenyl-2-pyrazoline-5-one or 3-amino-2-pyrazolin-5-one or cyanoacetic acid hydrazide. Structure and reacti