SYNTHESIS OF A PRECURSOR FOR THE PREPARATION OF 9α,11α-TRITIATED 5α-ANDROSTANE-3α,17β-DIOL 17-GLUCURONIDE

Article abstract of DOI:10.1016/0039-128X(84)90052-7

Starting from 11β-hydroxytestosterone, we achieved the synthesis of a strategic precursor, C-19(11) unsaturated 5α-androstane-3α,17β-diol 17-glucuronide (9a), for the preparation of 9α,11α-tritiated 5α-androstane-3α,17β-diol 17-glucuronide.We optimized the reaction conditions for catalytic reduction employing hydrogen and subsequent base hydrolysis followed by purification on Amberlite XAD-2 resin to obtain the saturated 5α-androstane-3α,17β-diol 17-glucuronide.