2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate

Base Information

• Chemical Name: 2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate
• CAS No.: 154044-76-5
• Molecular Formula: C₁₅H₁₈Cl₄O₅
• Molecular Weight: 420.117
• Mol file: 154044-76-5.mol

Synonyms:2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate

Chemical Property of 2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate

There total 2 articles about 2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1,2,2,2-tetrachloroethyl chloroformate (98015-53-3) + 2-methyl-1-(4-methoxyphenyl)methoxy-2-propanol (154044-75-4) → 2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate (154044-76-5)

Guidance literature:

With pyridine; In dichloromethane; at 5 ℃; for 6.5h;

DOI:10.1016/S0040-4020(01)81761-0

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → 2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate (154044-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / NaH / dimethylformamide / 1.) RT, 2 d; 2.) 60 deg C, 8 h

2: 50 percent / pyridine / CH₂Cl₂ / 6.5 h / 5 °C

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)81761-0

Reference yield: 53.0%

10-deacetyl-7,10-diTroc-baccatin III (114915-16-1) + 2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyl-1',2',2',2'-tetrachloroethyl-carbonate (154044-76-5) → N-de-t-butoxycarbonyl-N-2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyloxycarbonyl-7,10-O-diTroc-docetaxel (154044-74-3)

Guidance literature:

With pyridine; for 7h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81761-0

upstream raw materials:

1,2,2,2-tetrachloroethyl chloroformate

2-methyl-1-(4-methoxyphenyl)methoxy-2-propanol

4-Methoxybenzyl alcohol

Downstream raw materials:

N-de-t-butoxycarbonyl-N-2-<2-methyl-1-(4-methoxyphenyl)methoxy>propyloxycarbonyl-7,10-O-diTroc-docetaxel

RPR 104952

N-de-t-butoxycarbonyl-N-2-(1-hydroxy-2-methyl)propyloxycarbonyl-7,10-O-diTroc-docetaxel