15432-97-0

Basic information

• Product Name: 2-(2-methylphenyl)-1H-indene-1,3(2H)-dione
• CAS NO: 15432-97-0
• Molecular Formula: C₁₆H₁₂O₂
• Molecular Weight: 236.2653
• Mol File: 15432-97-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 423.9°C at 760 mmHg
• Flash Point: 158.4°C
• Density: 1.23g/cm³
• Vapor Pressure: 2.15E-07mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 2-(2-methylphenyl)-1H-indene-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methylphenyl)-1H-indene-1,3(2H)-dione(15432-97-0)
• EPA Substance Registry System: 2-(2-methylphenyl)-1H-indene-1,3(2H)-dione(15432-97-0)

Safety Data

• Hazardous Substances Data: 15432-97-0(Hazardous Substances Data)

Usage

Chemical class

Indene diones

Physical appearance

Yellow to orange solid substance

Solubility

Sparingly soluble in water

Uses

Organic synthesis, building block in production of pharmaceuticals, agrochemicals, and pigments

Potential properties

Antioxidant, anti-inflammatory

Medicinal applications

Potential but requires further research to understand its biological activities and potential uses.

Upstream product

• 1807-49-4 2-diazo-indan-1,3-dione 
• 108-88-3 toluene 
• 19844-27-0 1-(3,4-dichlorophenyl)pyrrole-2,5-dione 
• 100-52-7 benzaldehyde 
• 87-41-2 2-benzofuran-1(3H)-one 
• 529-20-4 2-methylphenyl aldehyde 
• 19391-29-8 3-(2-Methylbenzylidene)phthalide 
• 124-41-4 sodium methylate 

Downstream Products

• 53083-74-2 2,2-Dimethyl-propionic acid 3-oxo-2-o-tolyl-3H-inden-1-yl ester 
• 202820-08-4 2-bromo-2-(2-methylphenyl)indan-1,3-dione 
• 53083-76-4 Hexadecanoic acid 3-oxo-2-o-tolyl-3H-inden-1-yl ester 

Relevant articles and documents

Convenient and efficient synthesis of novel 11: H -benzo[5,6][1,4]thiazino[3,4- a] isoindol-11-ones derived from 2-bromo-(2/3-substitutedphenyl)-1 H -indene-1,3(2 H)-diones

An unprecedented formation of 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones through a one-step reaction of differently substituted 2-aminobenzenethiols and 2-bromo-(2/3-substitutedphenyl)-1H-indene-1,3(2H)-diones in freshly dried ethanol under reflux conditions has been investigated. This unique transformation probably occurs through an initial nucleophilic substitution followed by ring opening and subsequent intramolecular cyclization. The structures of all the synthesized benzo[1,4]thiazino isoindolinones were established by FTIR, 1H NMR, 13C NMR, HRMS, and X-ray crystallographic analysis. This approach was found to be simple and convenient and provides several advantages such as substantial atom economy, short reaction time and operational simplicity.

INDANONE AND INDANDIONE DERIVATIVES AND HETEROCYCLIC ANALOGS

The invention relates to indanone/indandione derivatives and heterocyclic analogs of Formula (I) wherein Ar1, A, B, L1, Y, Z, and (R1)n n are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as NPS receptor antagonists.

Rhodium(II) Acetate Catalysed Reactions of 2-Diazo-1,3-indandione and 2-Diazo-1-indanone with Various Substrates

Decomposition of 2-diazo-1,3-indandione (3) by rhodium(II) acetate (1) in cyclohexane and in benzene results in overall carbon-hydrogen insertion to give 2-substituted 1,3-indandiones.Anisole, 1, and 3 yield 2-(4-methoxyphenyl)-1,3-indandione (74 percent); benzenes substituted by a single methyl or halogen groups yield the corresponding ortho- and para-substitution products.Spirocyclopropanes are obtained by rhodium(II)-catalyzed additions of 3 to olefins; electron-deficient olefins do not give adducts.Substituted 4H-indenofuran-4-ones and 2,3-disubstituted spiroindene>-1',3'-diones are formed from rhodium(II)-catalyzed reactions of 3 with acetylenes.Reactions of 1 and 3 with cyclohexane, olefins, acetylenes, and arenes involve selective electrophilic carbenic or ylidic processes. 2-Diazo-1-indanone (4) is converted by 1 to 2,2'-bis (48).Thiophenol reacts with 4 and 1 to yield 2-(phenylthio)-1-indanone (49).Cyclopropanations of cyclohexene and styrene by 4 as catalyzed by 1 result in spiroheptane-7,2'-indan>-1-one (50) and 2-phenylspiroinden>-1'(3'H)-one (51), respectively.