374791-95-4

Basic information

• Product Name: cis-2-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-(2-oxa-8-azaspiro[4.5]dec-8-yl)-1-phenylcyclohexyl]propionamide
• CAS NO: 374791-95-4
• Molecular Formula: C₃₁H₃₆F₆N₂O₂
• Molecular Weight: 582.63517
• Mol File: 374791-95-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: cis-2-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-(2-oxa-8-azaspiro[4.5]dec-8-yl)-1-phenylcyclohexyl]propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: cis-2-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-(2-oxa-8-azaspiro[4.5]dec-8-yl)-1-phenylcyclohexyl]propionamide(374791-95-4)
• EPA Substance Registry System: cis-2-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-(2-oxa-8-azaspiro[4.5]dec-8-yl)-1-phenylcyclohexyl]propionamide(374791-95-4)

Safety Data

• Hazardous Substances Data: 374791-95-4(Hazardous Substances Data)

Upstream product

• 176-69-2 2-oxa-8-azaspiro[4.5]decane 
• 374791-10-3 (RS)-α-methyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide 
• 247133-32-0 4-ethoxycarbonyl-4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 146603-99-8 1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate 
• 236406-38-5 1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate 
• 374794-96-4 1,1-dimethylethyl 2-oxa-8-azaspiro[4,5]decane-8-carboxylate 
• 154348-08-0 1,1-dimethylethyl 1-oxo-2-oxa-8-azaspiro[4,5]decane-8-carboxylate 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 

Relevant articles and documents

4,4-Disubstituted cyclohexylamine NK1 receptor antagonists II

A series of novel 4,4-disubstituted cyclohexylamines as NK1 receptor antagonists is described: modifications to the amine moiety retain NK1 receptor binding affinity whilst disrupting IKr affinity.